Associated Papers
Neurodevelopmental Implications Underpinning Hereditary Spastic Paraplegia.
Zhi Y et al.
Cns Neuroscience & Therapeutics, 2025
39932116 (PubMed )
Supplement: CNS-31-e70260-s001.xlsx › SPG4
An allosteric network in spastin couples multiple activities required for microtubule severing.
Sandate CR et al.
Nature Structural & Molecular Biology, 2019
31285604 (PubMed )
Supplement: NIHMS1530257-supplement-3.pdf
Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia.
Zempel H et al.
Molecular Neurodegeneration, 2015
Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.
Solowska JM et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2014
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
Kasher PR et al.
Journal of Neurochemistry, 2009
Spastin oligomerizes into a hexamer and the mutant spastin (E442Q) redistribute the wild-type spastin into filamentous microtubule.
Pantakani DV et al.
Journal of Neurochemistry, 2008
Clinical features of hereditary spastic paraplegia due to spastin mutation.
McDermott CJ et al.
Neurology, 2006
Spastin mutations are frequent in sporadic spastic paraparesis and their spectrum is different from that observed in familial cases.
Depienne C et al.
Journal of Medical Genetics, 2006
Autosomal dominant hereditary spastic paraplegia: DHPLC-based mutation analysis of SPG4 reveals eleven novel mutations.
Patrono C et al.
Human Mutation, 2005
Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation.
McDermott CJ et al.
Annals of Neurology, 2003
The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene.
Wharton SB et al.
Journal of Neuropathology and Experimental Neurology, 2003
Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis.
Lindsey JC et al.
Journal of Medical Genetics, 2000
Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation.
White KD et al.
Neurology, 2000
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