Associated Papers
SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation.
Huang N et al.
Human Molecular Genetics, 2024
SPINT2 (HAI-2) missense variants identified in congenital sodium diarrhea/tufting enteropathy affect the ability of HAI-2 to inhibit prostasin but not matriptase.
Holt-Danborg L et al.
Human Molecular Genetics, 2019
HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase.
Nonboe AW et al.
Traffic (copenhagen, Denmark), 2017
Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 2.
Qin L et al.
Febs Letters, 1998
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