Varaico: Literature-Extracted Genetic Variants

Gene:SPOP
Variant:p.W131C
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SPOP

NM_001007228.2:p.W131C

Associated Papers

Molecular insights for the tumor suppressor role of SPOP in prostate cancer.

Yan P et al.

Biochimica Et Biophysica Acta. Reviews on Cancer, 2026

Blood-Based Genomic Alteration Signature for Predicting Progression-Free Survival in De Novo Metastatic Hormone-Sensitive Prostate Cancer: A Real-World Study.

Wang R et al.

Cancer Research Communications, 2025

41217768 (PubMed )
Supplement: crc-25-0384_supplementary_table_s2_suppst2.xlsx › Supplementary_Table_2

The equilibrium between two quaternary assembly states determines the activity of SPOP and its cancer mutants.

Cuneo MJ et al.

Biorxiv : the Preprint Server for Biology, 2025

Homologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional immunofluorescence.

Arce-Gallego S et al.

Cell Reports. Medicine, 2025

39914385 (PubMed )
Supplement: mmc1.pdf

Genomic profiling and clinical utility of circulating tumor DNA in metastatic prostate cancer: SCRUM-Japan MONSTAR SCREEN project.

Shiota M et al.

Bjc Reports, 2024

39516321 (PubMed )
Supplement: 44276_2024_49_MOESM4_ESM.xlsx › supplementary_table_2

Concordance and Clinical Significance of Genomic Alterations in Progressive Tumor Tissue and Matched Circulating Tumor DNA in Aggressive-variant Prostate Cancer.

Wang R et al.

Cancer Research Communications, 2023

37877742 (PubMed )
Supplement: crc-23-0175-s02.xls › Supplementary_Table_2

Opposing Roles of SPOP Mutations in Human Prostate and Endometrial Cancers.

Cavalcante L et al.

Jco Precision Oncology, 2023

Mass spectrometry-based targeted proteomics for analysis of protein mutations.

Lin TT et al.

Mass Spectrometry Reviews, 2023

Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.

White JA et al.

Cancer Research Communications, 2022

36922933 (PubMed )
Supplement: crc-22-0136-s01.xlsx › ST3_Known_Somatic_Variants

Detection of disease-causing mutations in prostate cancer by NGS sequencing.

Mangolini A et al.

Cell Biology International, 2022

35347810 (PubMed )
Supplement: CBIN-46-1047-s001.xlsx › Mutations

Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression.

Shi L et al.

Cancer Research, 2021

Somatic Evolution in Non-neoplastic IBD-Affected Colon.

Olafsson S et al.

Cell, 2020

32697969 (PubMed )
Supplement: mmc4.xlsx › A__TCGA_hotspots

Genomics of lethal prostate cancer at diagnosis and castration resistance.

Mateo J et al.

The Journal of Clinical Investigation, 2020

31874108 (PubMed )
Supplement: jci-130-132031-s102.xlsx › shared_calls_primary-mCRPC

The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Punta M et al.

Frontiers in Immunology, 2020

33133066 (PubMed )
Supplement: Table_1.xlsx › Drivers-not-HR

Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly.

Shi Q et al.

Molecular Cancer, 2019

The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer.

Yan Y et al.

Embo Molecular Medicine, 2019

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.

Ma J et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2018

Identification of SPOP related metabolic pathways in prostate cancer.

Yan M et al.

Oncotarget, 2017

Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics.

Wang H et al.

Journal of Translational Medicine, 2017

Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Chen F et al.

Nature Communications, 2017

28775315 (PubMed )
Supplement: 41467_2017_289_MOESM7_ESM.xlsx › mutation_data

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.

Jin X et al.

Plos Genetics, 2017

Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.

Kim E et al.

Cancer Discovery, 2016

Genetic Progression of High Grade Prostatic Intraepithelial Neoplasia to Prostate Cancer.

Jung SH et al.

European Urology, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."