Associated Papers
The equilibrium between two quaternary assembly states determines the activity of SPOP and its cancer mutants.
Cuneo MJ et al.
Biorxiv : the Preprint Server for Biology, 2025
SPOP mutations increase PARP inhibitor sensitivity via CK2/PIAS1/SPOP axis in prostate cancer.
Zhang H et al.
Jci Insight, 2025
SPOP point mutations regulate substrate preference and affect its function.
Deng Y et al.
Cell Death & Disease, 2024
SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer.
Shi Q et al.
Cell Death and Differentiation, 2022
Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression.
Shi L et al.
Cancer Research, 2021
ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Wang D et al.
Science Advances, 2021
The Roles of SPOP in DNA Damage Response and DNA Replication.
Maekawa M et al.
International Journal of Molecular Sciences, 2020
SPOP Deregulation Improves the Radiation Response of Prostate Cancer Models by Impairing DNA Damage Repair.
El Bezawy R et al.
Cancers, 2020
Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly.
Shi Q et al.
Molecular Cancer, 2019
SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.
Ma J et al.
Journal of Experimental & Clinical Cancer Research : Cr, 2018
SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG.
Shoag J et al.
The Journal of Clinical Investigation, 2018
29202479 (PubMed )
Supplement: jci-128-96551-s001.pdf
Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.
Jin X et al.
Plos Genetics, 2017
Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants.
Zhang P et al.
Human Mutation, 2014
SPOP mutations in prostate cancer across demographically diverse patient cohorts.
Blattner M et al.
Neoplasia (new York, N.y.), 2014
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover.
Geng C et al.
Proceedings of the National Academy of Sciences of the United States of America, 2013
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