Associated Papers
Molecular analysis of the evolutionary history of endometrial and ovarian carcinoma in Lynch syndrome.
Kauppinen AK et al.
International Journal of Cancer, 2025
The equilibrium between two quaternary assembly states determines the activity of SPOP and its cancer mutants.
Cuneo MJ et al.
Biorxiv : the Preprint Server for Biology, 2025
Clinical Insights Into Nabais Sá-De Vries Syndrome due to a Novel SPOP Mutation: Neuromotor, Cognitive, Adaptive, Behavioral, and Neurovisual Features.
Galli J et al.
American Journal of Medical Genetics. Part A, 2025
Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy.
Huang J et al.
Frontiers in Immunology, 2025
SPOP point mutations regulate substrate preference and affect its function.
Deng Y et al.
Cell Death & Disease, 2024
Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP.
Sabri N et al.
The Journal of Biological Chemistry, 2023
Opposing Roles of SPOP Mutations in Human Prostate and Endometrial Cancers.
Cavalcante L et al.
Jco Precision Oncology, 2023
Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP.
Sabri N et al.
Biorxiv : the Preprint Server for Biology, 2023
Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation.
Cuneo MJ et al.
Molecular Cell, 2023
SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1-PD-L1 axis.
Gao K et al.
Cell Death and Differentiation, 2023
Nabais Sa-de Vries syndrome in a Chinese infant associated with a novel SPOP mutation: A clinical study and genetic report.
Hu W et al.
Molecular Genetics & Genomic Medicine, 2022
The Roles of SPOP in DNA Damage Response and DNA Replication.
Maekawa M et al.
International Journal of Molecular Sciences, 2020
The mutational landscape of normal human endometrial epithelium.
Moore L et al.
Nature, 2020
De Novo Variants in SPOP Cause Two Clinically Distinct Neurodevelopmental Disorders.
Nabais Sá MJ et al.
American Journal of Human Genetics, 2020
Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.
Dong X et al.
Communications Biology, 2020
The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.
Punta M et al.
Frontiers in Immunology, 2020
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.
Janouskova H et al.
Nature Medicine, 2017
Genetic analysis of uterine adenosarcomas and phyllodes tumors of the breast.
Geyer FC et al.
Molecular Oncology, 2017
Targeted mutation analysis of endometrial clear cell carcinoma.
Hoang LN et al.
Histopathology, 2015
Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover.
Zhang P et al.
Cell Death & Disease, 2015
Mutational landscape and significance across 12 major cancer types.
Kandoth C et al.
Nature, 2013
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.
Le Gallo M et al.
Nature Genetics, 2012