Varaico: Literature-Extracted Genetic Variants

Gene:SPOP
Variant:p.E50K
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SPOP

NM_001007228.2:p.E50K

Associated Papers

Comparative Analysis of a Dual DNA-RNA Panel and a DNA-Only Panel for Sarcoma: Real-World Data From a Nationwide Genomic Database.

Nakata E et al.

Cancer Science, 2026

41128349 (PubMed )
Supplement: CAS-117-156-s003.xlsx › Sheet1

The equilibrium between two quaternary assembly states determines the activity of SPOP and its cancer mutants.

Cuneo MJ et al.

Biorxiv : the Preprint Server for Biology, 2025

Cul3 substrate adaptor SPOP targets Nup153 for degradation.

Ong JY et al.

Molecular Biology of the Cell, 2025

The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs).

Zhang L et al.

Elife, 2024

39688960 (PubMed )
Supplement: elife-99340-supp1.xlsx › CDN.Missense.gnomad

Pervasive mislocalization of pathogenic coding variants underlying human disorders.

Lacoste J et al.

Cell, 2024

Pervasive mislocalization of pathogenic coding variants underlying human disorders.

Lacoste J et al.

Biorxiv : the Preprint Server for Biology, 2023

Opposing Roles of SPOP Mutations in Human Prostate and Endometrial Cancers.

Cavalcante L et al.

Jco Precision Oncology, 2023

Cul3 substrate adaptor SPOP targets Nup153 for degradation.

Ong JY et al.

Biorxiv : the Preprint Server for Biology, 2023

Validation and Clinical Application of ONCOaccuPanel for Targeted Next-Generation Sequencing of Solid Tumors.

Kim M et al.

Cancer Research and Treatment, 2023

Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan.

Kage H et al.

Cancer Science, 2023

36601953 (PubMed )
Supplement: CAS-114-1710-s001.xlsx › Sup_Table_3

SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1-PD-L1 axis.

Gao K et al.

Cell Death and Differentiation, 2023

Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study.

Aoyagi Y et al.

Plos One, 2022

35358259 (PubMed )
Supplement: pone.0266112.s001.xlsx › Patients

Next-Generation Sequencing-Directed Therapy in Patients with Metastatic Breast Cancer in Routine Clinical Practice.

Bruzas S et al.

Cancers, 2021

34572791 (PubMed )
Supplement: cancers-13-04564-s001.zip › cancers-1336427-supplementary › Supplementary_material › Table_S1_-_Genetic_alterations_identified_by_NGS_in_95_patients_with_metastatic_breast_cancer.xlsx › Table_S1

Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project.

Lee Y et al.

Cancer Research and Treatment, 2021

Gene polymorphism-related differences in the outcomes of abiraterone for prostate cancer: a systematic overview.

Liu M et al.

American Journal of Cancer Research, 2021

The Roles of SPOP in DNA Damage Response and DNA Replication.

Maekawa M et al.

International Journal of Molecular Sciences, 2020

The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Punta M et al.

Frontiers in Immunology, 2020

33133066 (PubMed )
Supplement: Table_1.xlsx › Drivers-not-HR

The ubiquitin ligase adaptor SPOP in cancer.

Cuneo MJ et al.

The Febs Journal, 2019

Genomic Comparison of Endometrioid Endometrial Carcinoma and Its Precancerous Lesions in Chinese Patients by High-Depth Next Generation Sequencing.

Wang Y et al.

Frontiers in Oncology, 2019

30886832 (PubMed )
Supplement: Table_2.xls › Table_2

SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity.

Boysen G et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2018

Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.

Janouskova H et al.

Nature Medicine, 2017

Next-Generation Sequencing.

Le Gallo M et al.

Advances in Experimental Medicine and Biology, 2017

Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas.

Karnezis AN et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2016

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover.

Zhang P et al.

Cell Death & Disease, 2015

Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.

Theurillat JP et al.

Science (new York, N.y.), 2014

Integrated genomic characterization of endometrial carcinoma.

Kandoth C et al.

Nature, 2013

23636398 (PubMed )
Supplement: 41586_2013_BFnature12113_MOESM88_ESM.pdf
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."