Associated Papers
PARP1 recruits SPRTN to DNA-protein crosslinks through a conserved poly-ADP-ribose binding domain.
Hurley K et al.
Biorxiv : the Preprint Server for Biology, 2026
Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes.
Saha LK et al.
Nature Communications, 2023
USP1-trapping lesions as a source of DNA replication stress and genomic instability.
Coleman KE et al.
Nature Communications, 2022
Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease.
Perry M et al.
Frontiers in Molecular Biosciences, 2022
Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes.
Saha LK et al.
Nucleic Acids Research, 2021
SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.
Na J et al.
Cell Death & Disease, 2021
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.
Halder S et al.
Nature Communications, 2019
Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.
Maskey RS et al.
Nucleic Acids Research, 2017
SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks.
Lopez-Mosqueda J et al.
Elife, 2016
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.
Vaz B et al.
Molecular Cell, 2016
Spartan deficiency causes genomic instability and progeroid phenotypes.
Maskey RS et al.
Nature Communications, 2014
USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.
Perry M et al.
The Journal of Biological Chemistry, 0
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