Associated Papers
Cancer-associated mutations in autophagy-related proteins analyzed in yeast and human cells.
Lei Y et al.
Autophagy, 2025
The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B.
Alcober-Boquet L et al.
Protein Science : a Publication of the Protein Society, 2024
S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy.
Huang X et al.
Molecular Cell, 2023
The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy.
Gallagher ER et al.
Cell Reports, 2023
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy.
Xia Q et al.
Cell & Bioscience, 2023
Vault RNA1-1 riboregulates the autophagic function of p62 by binding to lysine 7 and arginine 21, both of which are critical for p62 oligomerization.
Büscher M et al.
Rna (new York, N.y.), 2022
TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins.
Lyu L et al.
Autophagy, 2022
Structure and function of p62/SQSTM1 in the emerging framework of phase separation.
Berkamp S et al.
The Febs Journal, 2021
p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death.
Foster AD et al.
Scientific Reports, 2021
SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells.
Nozaki M et al.
Eneurologicalsci, 2021
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
Tan CT et al.
Embo Reports, 2021
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.
Kageyama S et al.
Nature Communications, 2021
The role of sequestosome 1/p62 protein in amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis.
Foster AD et al.
Neural Regeneration Research, 2020
NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.
Sánchez-Martín P et al.
Embo Reports, 2020
NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.
Shrestha BK et al.
The Journal of Biological Chemistry, 2020
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.
Jakobi AJ et al.
Nature Communications, 2020
Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress.
You Z et al.
Nature Communications, 2019
TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1.
Overå KS et al.
Journal of Cell Science, 2019
Oligomer Model of PB1 Domain of p62/SQSTM1 Based on Crystal Structure of Homo-Dimer and Calculation of Helical Characteristics.
Lim D et al.
Molecules and Cells, 2019
Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response.
Yang Y et al.
Nature Communications, 2019
p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress.
Wang L et al.
Plos Pathogens, 2019
pH-dependent regulation of SQSTM1/p62 during autophagy.
Kwon DH et al.
Autophagy, 2019
PB1 and UBA domains of p62 are essential for aggresome-like induced structure formation.
Cabe M et al.
Biochemical and Biophysical Research Communications, 2018
Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter.
Kwon DH et al.
Nature Communications, 2018
Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant.
Kageyama S et al.
Molecular and Cellular Biology, 2018
USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination.
Sharma A et al.
Autophagy, 2018
The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy.
Lin Q et al.
Journal of Cell Science, 2017
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.
Cha-Molstad H et al.
Nature Communications, 2017
Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance.
Hewitt G et al.
Trends in Cell Biology, 2017
Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.
Peng H et al.
Cell Research, 2017
Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination.
Lee Y et al.
Cell Reports, 2017
Autophagy substrate SQSTM1/p62 regulates chromatin ubiquitination during the DNA damage response.
Wang Y et al.
Autophagy, 2017
Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62.
Wang Y et al.
Molecular Cell, 2016
Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease.
Song P et al.
Protein & Cell, 2016
Autophagy regulates DNA repair by modulating histone ubiquitination.
Wang Y et al.
Molecular & Cellular Oncology, 2016
Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.
Linares JF et al.
Cell Reports, 2015
The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.
Ma B et al.
The Journal of Biological Chemistry, 2015
PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding.
Christian F et al.
Biochimica Et Biophysica Acta, 2014
Structural and biochemical insights into the homotypic PB1-PB1 complex between PKCζ and p62.
Ren J et al.
Science China. Life Sciences, 2014