Varaico: Literature-Extracted Genetic Variants

Gene:SQSTM1
Variant:p.S349A
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SQSTM1

NM_003900.5:p.S349A

Associated Papers

DNA damage response pathway regulates Nrf2 in response to oxidative stress.

Jiang XY et al.

Science Advances, 2025

KEAP1 retention in phase-separated p62 bodies drives liver damage under autophagy-deficient conditions.

Takada S et al.

Embo Reports, 2025

Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease.

Cazzaro S et al.

Proceedings of the National Academy of Sciences of the United States of America, 2023

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.

Ikeda R et al.

The Embo Journal, 2023

Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy.

Xia Q et al.

Cell & Bioscience, 2023

NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.

Sánchez-Martín P et al.

Embo Reports, 2020

TFEB activates Nrf2 by repressing its E3 ubiquitin ligase DCAF11 and promoting phosphorylation of p62.

Park JY et al.

Scientific Reports, 2019

VPS34 stimulation of p62 phosphorylation for cancer progression.

Jiang X et al.

Oncogene, 2017

Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.

Peng H et al.

Cell Research, 2017

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

Ichimura Y et al.

Molecular Cell, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."