Associated Papers
KEAP1 retention in phase-separated p62 bodies drives liver damage under autophagy-deficient conditions.
Takada S et al.
Embo Reports, 2025
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.
Ikeda R et al.
The Embo Journal, 2023
Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity.
Faruk MO et al.
The Journal of Biological Chemistry, 2021
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.
Kageyama S et al.
Nature Communications, 2021
Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease.
Yamada T et al.
Cell Metabolism, 2018
Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination.
Lee Y et al.
Cell Reports, 2017
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Ichimura Y et al.
Molecular Cell, 2013
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
Jain A et al.
The Journal of Biological Chemistry, 2010
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