Associated Papers
Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy.
Chiu PH et al.
Cell Reports. Medicine, 2025
The type 1 diabetes candidate genes PTPN2 and BACH2 regulate the IFN-α-induced crosstalk between JAK/STAT and MAPKs pathways in human beta cells.
Roca-Rivada A et al.
Ebiomedicine, 2025
The type 1 diabetes candidate genes PTPN2 and BACH2 regulate novel IFN-α-induced crosstalk between the JAK/STAT and MAPKs pathways in human beta cells.
Rivada AR et al.
Research Square, 2025
Elevated Type I Interferon Signaling Defines the Proliferative Advantage of ARF and p53 Mutant Tumor Cells.
Mabry A et al.
Molecular and Cellular Biology, 2025
Elevated type I interferon signaling defines the proliferative advantage of ARF and p53 mutant tumor cells.
Mabry A et al.
Biorxiv : the Preprint Server for Biology, 2024
Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon.
Ghosh C et al.
Developmental Cell, 2024
STAT1 is required to establish but not maintain interferon-γ-induced transcriptional memory.
Tehrani SS et al.
The Embo Journal, 2023
Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.
Spens AE et al.
Elife, 2023
Pro-atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation.
Al-Ahmadi W et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2021
Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages.
Gupte R et al.
Nature Communications, 2021
Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity Development.
Chodisetti SB et al.
Journal of Immunology (baltimore, Md. : 1950), 2020
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Zuo Y et al.
Nature Communications, 2020
STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity.
Meissl K et al.
Frontiers in Immunology, 2020
ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination.
Zhang Y et al.
Bmc Cancer, 2018
The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment.
Parrini M et al.
Frontiers in Immunology, 2018
The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1.
Wu M et al.
American Journal of Physiology. Renal Physiology, 2016
Response to interferons and antibacterial innate immunity in the absence of tyrosine-phosphorylated STAT1.
Majoros A et al.
Embo Reports, 2016
STAT1 plays a role in TLR signal transduction and inflammatory responses.
Luu K et al.
Immunology and Cell Biology, 2014
Regulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism.
Burke SJ et al.
Molecular Endocrinology (baltimore, Md.), 2013
CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response.
Bancerek J et al.
Immunity, 2013
Smurf1 protein negatively regulates interferon-γ signaling through promoting STAT1 protein ubiquitination and degradation.
Yuan C et al.
The Journal of Biological Chemistry, 2012
Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin.
Fielhaber JA et al.
The Journal of Biological Chemistry, 2012
STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas.
Chan SR et al.
Breast Cancer Research : Bcr, 2012
Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene.
Auriemma LB et al.
Epigenetics & Chromatin, 2012
Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation.
Friedbichler K et al.
Frontiers in Bioscience (landmark Edition), 2011
Signal transducer and activator of transcription 1 negatively regulates constitutive gamma interferon-inducible lysosomal thiol reductase expression.
Srinivasan P et al.
Immunology, 2011
Importance of serine727 phosphorylated STAT1 in IFNγ-induced signaling and apoptosis of human salivary gland cells.
Tsuboi H et al.
International Journal of Rheumatic Diseases, 2011
GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
Oh M et al.
The Journal of Biological Chemistry, 2009
Stat1 is an inhibitor of Ras-MAPK signaling and Rho small GTPase expression with implications in the transcriptional signature of Ras transformed cells.
Wang S et al.
Cell Cycle (georgetown, Tex.), 2009
Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains.
Wojciak JM et al.
The Embo Journal, 2009
ERK and the F-box protein betaTRCP target STAT1 for degradation.
Soond SM et al.
The Journal of Biological Chemistry, 2008
The interferon-stimulated gene factor 3 complex mediates the inhibitory effect of interferon-beta on matrix metalloproteinase-9 expression.
Zhao X et al.
The Febs Journal, 2007
STAT1 regulates p73-mediated Bax gene expression.
Soond SM et al.
Febs Letters, 2007
Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis.
Timofeeva OA et al.
Oncogene, 2006
Nuclear export determines the cytokine sensitivity of STAT transcription factors.
Lödige I et al.
The Journal of Biological Chemistry, 2005
Signaling through a mutant IFN-gamma receptor.
Costa-Pereira AP et al.
Journal of Immunology (baltimore, Md. : 1950), 2005
Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity.
Varinou L et al.
Immunity, 2003
Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates.
Zakharova N et al.
The Journal of Biological Chemistry, 2003
Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons.
Pilz A et al.
Embo Reports, 2003
IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression.
Nguyen H et al.
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research, 2003
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei.
Wu TR et al.
The Journal of Biological Chemistry, 2002
Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1.
Stewart MD et al.
Biology of Reproduction, 2002