Associated Papers
Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy.
Chiu PH et al.
Cell Reports. Medicine, 2025
The type 1 diabetes candidate genes PTPN2 and BACH2 regulate the IFN-α-induced crosstalk between JAK/STAT and MAPKs pathways in human beta cells.
Roca-Rivada A et al.
Ebiomedicine, 2025
Threonine phosphorylation of STAT1 safeguards gut epithelial integrity and restricts interferon-mediated cytotoxicity.
Metwally H et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
The type 1 diabetes candidate genes PTPN2 and BACH2 regulate novel IFN-α-induced crosstalk between the JAK/STAT and MAPKs pathways in human beta cells.
Rivada AR et al.
Research Square, 2025
Elevated Type I Interferon Signaling Defines the Proliferative Advantage of ARF and p53 Mutant Tumor Cells.
Mabry A et al.
Molecular and Cellular Biology, 2025
Elevated type I interferon signaling defines the proliferative advantage of ARF and p53 mutant tumor cells.
Mabry A et al.
Biorxiv : the Preprint Server for Biology, 2024
Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.
Metwally H et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon.
Ghosh C et al.
Developmental Cell, 2024
Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease.
Hao W et al.
Cell Death & Disease, 2023
Lack of STAT1 co-operative DNA binding protects against adverse cardiac remodelling in acute myocardial infarction.
Doudin A et al.
Frontiers in Cardiovascular Medicine, 2023
An inhibitory effect on the nuclear accumulation of phospho-STAT1 by its unphosphorylated form.
Menon PR et al.
Cell Communication and Signaling : Ccs, 2022
The tyrosine kinase c-Abl potentiates interferon-mediated antiviral immunity by STAT1 phosphorylation.
Liu H et al.
Iscience, 2021
δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease.
Zhang Z et al.
Molecular Psychiatry, 2021
Interactions of the Nipah Virus P, V, and W Proteins across the STAT Family of Transcription Factors.
Keiffer TR et al.
Msphere, 2020
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Zuo Y et al.
Nature Communications, 2020
Selenium-binding protein 1 transcriptionally activates p21 expression via p53-independent mechanism and its frequent reduction associates with poor prognosis in bladder cancer.
Wang Y et al.
Journal of Translational Medicine, 2020
Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1.
Layoun A et al.
Scientific Reports, 2019
Tau accumulation triggers STAT1-dependent memory deficits by suppressing NMDA receptor expression.
Li XG et al.
Embo Reports, 2019
Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.
Prutsch N et al.
Leukemia, 2019
ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination.
Zhang Y et al.
Bmc Cancer, 2018
A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses.
Michalska A et al.
Frontiers in Immunology, 2018
Interferon-beta represses cancer stem cell properties in triple-negative breast cancer.
Doherty MR et al.
Proceedings of the National Academy of Sciences of the United States of America, 2017
STAT1β enhances STAT1 function by protecting STAT1α from degradation in esophageal squamous cell carcinoma.
Zhang Y et al.
Cell Death & Disease, 2017
STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways.
Ho J et al.
Plos Biology, 2016
Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity.
Yang S et al.
Scientific Reports, 2016
The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1.
Wu M et al.
American Journal of Physiology. Renal Physiology, 2016
Response to interferons and antibacterial innate immunity in the absence of tyrosine-phosphorylated STAT1.
Majoros A et al.
Embo Reports, 2016
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Zhang Y et al.
Nature Immunology, 2015
STAT3 but not STAT1 is required for astrocyte differentiation.
Hong S et al.
Plos One, 2014
Trypanosoma cruzi evades the protective role of interferon-gamma-signaling in parasite-infected cells.
Stahl P et al.
Plos One, 2014
Regulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism.
Burke SJ et al.
Molecular Endocrinology (baltimore, Md.), 2013
A rapid conformational rearrangement of STAT1 dimers is required for termination rather than for amplification of interferon-γ signaling.
Staab J et al.
Jak-stat, 2013
Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1.
Grönholm J et al.
Bmc Biochemistry, 2012
Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation.
Ginter T et al.
Cellular Signalling, 2012
Smurf1 protein negatively regulates interferon-γ signaling through promoting STAT1 protein ubiquitination and degradation.
Yuan C et al.
The Journal of Biological Chemistry, 2012
The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
Bailey AD et al.
Dna Repair, 2012
Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin.
Fielhaber JA et al.
The Journal of Biological Chemistry, 2012
STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas.
Chan SR et al.
Breast Cancer Research : Bcr, 2012
STAT1 signaling is not regulated by a phosphorylation-acetylation switch.
Antunes F et al.
Molecular and Cellular Biology, 2011
Signal transducer and activator of transcription 1 negatively regulates constitutive gamma interferon-inducible lysosomal thiol reductase expression.
Srinivasan P et al.
Immunology, 2011
Importance of serine727 phosphorylated STAT1 in IFNγ-induced signaling and apoptosis of human salivary gland cells.
Tsuboi H et al.
International Journal of Rheumatic Diseases, 2011