Associated Papers
A hyperactive splice variant of STAT3 promotes colonic inflammation-associated tumorigenesis in mice.
Xu M et al.
Science Translational Medicine, 2025
The critical role of the phosphorylation of STAT3 at Y705 in ALCL-associated NPM-ALK-induced transforming activity.
Lin X et al.
Cellular Signalling, 2025
Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy.
Chiu PH et al.
Cell Reports. Medicine, 2025
Elevated type I interferon signaling defines the proliferative advantage of ARF and p53 mutant tumor cells.
Mabry A et al.
Biorxiv : the Preprint Server for Biology, 2024
Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor.
Diallo M et al.
Cellular Oncology (dordrecht, Netherlands), 2024
STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer.
D'Amico S et al.
Elife, 2024
The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.
Korai A et al.
Cellular Signalling, 2024
Structural determinants of mitochondrial STAT3 targeting and function.
Marié IJ et al.
Mitochondrial Communications, 2024
STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness.
Arévalo J et al.
Scientific Reports, 2023
STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer.
D'Amico S et al.
Biorxiv : the Preprint Server for Biology, 2023
Analysis of Radiation Toxicity in Mammalian Cells Stably Transduced with Mitochondrial Stat3.
Zanin A et al.
International Journal of Molecular Sciences, 2023
Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.
Spens AE et al.
Elife, 2023
Non-canonical STAT3 function reduces REDD1 transcription.
Köhler N et al.
The Febs Journal, 2023
The role of understudied post-translational modifications for the behavior and function of Signal Transducer and Activator of Transcription 3.
Diallo M et al.
The Febs Journal, 2022
SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo.
Wang Y et al.
Cancer Letters, 2022
Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer.
Alhayyani S et al.
Oncogene, 2022
SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut.
Yu W et al.
Cellular and Molecular Gastroenterology and Hepatology, 2022
Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function.
Comità S et al.
Basic Research in Cardiology, 2021
Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.
Peron M et al.
Development (cambridge, England), 2021
The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions.
Tesoriere A et al.
Biomedicines, 2021
Mitochondrial STAT3 regulates antioxidant gene expression through complex I-derived NAD in triple negative breast cancer.
Lahiri T et al.
Molecular Oncology, 2021
The miR-19b-3p-MAP2K3-STAT3 feedback loop regulates cell proliferation and invasion in esophageal squamous cell carcinoma.
Zhang Y et al.
Molecular Oncology, 2021
Nuclear and cytosolic pS727-STAT3 levels correlate with overall survival of patients affected by clear cell renal cell carcinoma (ccRCC).
Arévalo J et al.
Scientific Reports, 2021
NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy.
Koerdel K et al.
Cancers, 2021
Emerging therapeutic targets for cardiac arrhythmias: role of STAT3 in regulating cardiac fibroblast function.
Patel NJ et al.
Expert Opinion on Therapeutic Targets, 2021
Noncanonical pS727 post translational modification dictates major STAT3 activation and downstream functions in breast cancer.
Dimri S et al.
Experimental Cell Research, 2020
Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer.
Chun KS et al.
Cells, 2020
STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression.
Balic JJ et al.
Nature Communications, 2020
Phospho-Ser727 triggers a multistep inactivation of STAT3 by rapid dissociation of pY705-SH2 through C-terminal tail modulation.
Yang J et al.
International Immunology, 2020
Can asymmetric post-translational modifications regulate the behavior of STAT3 homodimers?
Letra-Vilela R et al.
Faseb Bioadvances, 2020
Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity.
Balic JJ et al.
Cancer Research, 2019
A role for polycystin-1 and polycystin-2 in neural progenitor cell differentiation.
Winokurow N et al.
Cellular and Molecular Life Sciences : Cmls, 2019
STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH.
Liu B et al.
Cell Research, 2018
The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma.
Ganguly D et al.
Oncotarget, 2018
STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle.
Morgan EL et al.
Plos Pathogens, 2018
Recent Developments on the Crosstalk Between STAT3 and Inflammation in Heart Function and Disease.
Kurdi M et al.
Frontiers in Immunology, 2018
Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells.
Banerjee K et al.
Cellular Signalling, 2017
The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity.
Xiao Y et al.
The Journal of Experimental Medicine, 2017
Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation.
Li X et al.
The Journal of Experimental Medicine, 2017
Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity.
Hsia HC et al.
The Journal of Biological Chemistry, 2017
Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma.
Makino Y et al.
Biochemical and Biophysical Research Communications, 2017
STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism.
Xu YS et al.
Scientific Reports, 2016