Associated Papers
A hyperactive splice variant of STAT3 promotes colonic inflammation-associated tumorigenesis in mice.
Xu M et al.
Science Translational Medicine, 2025
The critical role of the phosphorylation of STAT3 at Y705 in ALCL-associated NPM-ALK-induced transforming activity.
Lin X et al.
Cellular Signalling, 2025
A-485 alleviates fibrosis and apoptosis in kidney by disrupting tandem activation of acetylation and phosphorylation on STAT3.
Du C et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2025
PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury.
Zhao H et al.
Free Radical Biology & Medicine, 2024
Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor.
Diallo M et al.
Cellular Oncology (dordrecht, Netherlands), 2024
Oncostatin M signaling drives cancer-associated skeletal muscle wasting.
Domaniku-Waraich A et al.
Cell Reports. Medicine, 2024
STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer.
D'Amico S et al.
Elife, 2024
The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.
Korai A et al.
Cellular Signalling, 2024
Unraveling the unphosphorylated STAT3-unphosphorylated NF-κB pathway in loss of function STAT3 Hyper IgE syndrome.
Karim A et al.
Frontiers in Immunology, 2024
The novel role of LOC344887 in the enhancement of hepatocellular carcinoma progression via modulation of SHP1-regulated STAT3/HMGA2 signaling axis.
Lin YH et al.
International Journal of Biological Sciences, 2024
STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness.
Arévalo J et al.
Scientific Reports, 2023
STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer.
D'Amico S et al.
Biorxiv : the Preprint Server for Biology, 2023
Non-canonical STAT3 function reduces REDD1 transcription.
Köhler N et al.
The Febs Journal, 2023
Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers.
Kasembeli MM et al.
Blood, 2023
The role of understudied post-translational modifications for the behavior and function of Signal Transducer and Activator of Transcription 3.
Diallo M et al.
The Febs Journal, 2022
SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo.
Wang Y et al.
Cancer Letters, 2022
TRIM32 promotes radioresistance by disrupting TC45-STAT3 interaction in triple-negative breast cancer.
Ma Y et al.
Oncogene, 2022
Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer.
Alhayyani S et al.
Oncogene, 2022
Recent advances in understanding the molecular role of phosphoinositide-specific phospholipase C gamma 1 as an emerging onco-driver and novel therapeutic target in human carcinogenesis.
Mandal S et al.
Biochimica Et Biophysica Acta. Reviews on Cancer, 2021
Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.
Peron M et al.
Development (cambridge, England), 2021
The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions.
Tesoriere A et al.
Biomedicines, 2021
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance.
Asano T et al.
The Journal of Experimental Medicine, 2021
Antagonism of STAT3 signalling by Ebola virus.
Harrison AR et al.
Plos Pathogens, 2021
The miR-19b-3p-MAP2K3-STAT3 feedback loop regulates cell proliferation and invasion in esophageal squamous cell carcinoma.
Zhang Y et al.
Molecular Oncology, 2021
CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner.
Zhai W et al.
British Journal of Cancer, 2021
Nuclear and cytosolic pS727-STAT3 levels correlate with overall survival of patients affected by clear cell renal cell carcinoma (ccRCC).
Arévalo J et al.
Scientific Reports, 2021
Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression.
Kim SJ et al.
Cancer Letters, 2021
A short deletion in the DNA-binding domain of STAT3 suppresses growth and progression of colon cancer cells.
Xiong YJ et al.
Aging, 2021
NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy.
Koerdel K et al.
Cancers, 2021
Emerging therapeutic targets for cardiac arrhythmias: role of STAT3 in regulating cardiac fibroblast function.
Patel NJ et al.
Expert Opinion on Therapeutic Targets, 2021
Noncanonical pS727 post translational modification dictates major STAT3 activation and downstream functions in breast cancer.
Dimri S et al.
Experimental Cell Research, 2020
Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis.
Lee YK et al.
Cancers, 2020
Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.
White CW et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020
Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
La Sala G et al.
Nature Communications, 2020
Can asymmetric post-translational modifications regulate the behavior of STAT3 homodimers?
Letra-Vilela R et al.
Faseb Bioadvances, 2020
DDIAS promotes STAT3 activation by preventing STAT3 recruitment to PTPRM in lung cancer cells.
Im JY et al.
Oncogenesis, 2020
Direct Targeting Options for STAT3 and STAT5 in Cancer.
Orlova A et al.
Cancers, 2019
A deep intronic splice mutation of STAT3 underlies hyper IgE syndrome by negative dominance.
Khourieh J et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease.
Wang ZH et al.
Cell Reports, 2019