Varaico: Literature-Extracted Genetic Variants

Gene:STAT3
Variant:p.K685R
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STAT3

NM_139276.3:p.K685R

Associated Papers

Post-translational modifications of Stat3: The state of the art.

Chen J et al.

Cellular Signalling, 2025

The effects of STAT3 acetylation on the transcriptional activity and tumorigenesis.

Yan H et al.

Biochemical Pharmacology, 2025

A-485 alleviates fibrosis and apoptosis in kidney by disrupting tandem activation of acetylation and phosphorylation on STAT3.

Du C et al.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2025

Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor.

Diallo M et al.

Cellular Oncology (dordrecht, Netherlands), 2024

The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.

Korai A et al.

Cellular Signalling, 2024

Unraveling the unphosphorylated STAT3-unphosphorylated NF-κB pathway in loss of function STAT3 Hyper IgE syndrome.

Karim A et al.

Frontiers in Immunology, 2024

The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions.

Tesoriere A et al.

Biomedicines, 2021

Noncanonical pS727 post translational modification dictates major STAT3 activation and downstream functions in breast cancer.

Dimri S et al.

Experimental Cell Research, 2020

Can asymmetric post-translational modifications regulate the behavior of STAT3 homodimers?

Letra-Vilela R et al.

Faseb Bioadvances, 2020

Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice.

Chen YC et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2019

Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor.

Kang HJ et al.

Oncotarget, 2017

STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism.

Xu YS et al.

Scientific Reports, 2016

Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts.

Albrengues J et al.

Nature Communications, 2015

Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3.

Dasgupta M et al.

The Journal of Biological Chemistry, 2014

Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.

Wang H et al.

The Journal of Biological Chemistry, 2010

Acetylation and activation of STAT3 mediated by nuclear translocation of CD44.

Lee JL et al.

The Journal of Cell Biology, 2009

LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation.

Ohbayashi N et al.

Biological & Pharmaceutical Bulletin, 2007

Structure, function, and regulation of STAT proteins.

Lim CP et al.

Molecular Biosystems, 2006

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.

Wang R et al.

The Journal of Biological Chemistry, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."