Varaico: Literature-Extracted Genetic Variants

Gene:STAT3
Variant:p.D661H
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STAT3

NM_139276.3:p.D661H

Associated Papers

STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs.

Lee HK et al.

Journal of Cellular and Molecular Medicine, 2026

Mouse Model of STAT3 Mutation Resulting in Job's Syndrome Diverges from Human Pathology.

Jankowski J et al.

International Journal of Molecular Sciences, 2025

SBNO2 is a critical mediator of STAT3-driven hematological malignancies.

Brandstoetter T et al.

Blood, 2023

Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Kar SP et al.

Nature Genetics, 2022

35835912 (PubMed )
Supplement: 41588_2022_1121_MOESM3_ESM.xlsx › ST3

STAT3 mutations in "gray-zone" cases of T-cell large granular lymphocytic leukemia associated with autoimmune rheumatic diseases.

Gorodetskiy V et al.

Frontiers in Medicine, 2022

Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma.

Frontzek F et al.

Nature Communications, 2021

34465776 (PubMed )
Supplement: 41467_2021_25405_MOESM9_ESM.xlsx › Targeted_resequencing_results

Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype.

Faletti L et al.

Biomedical Journal, 2021

Analysis of a single-institution cohort of patients with Felty's syndrome and T-cell large granular lymphocytic leukemia in the setting of rheumatoid arthritis.

Gorodetskiy VR et al.

Rheumatology International, 2021

Simultaneous Presentation of Leukemic Non-Nodal Mantle Cell Lymphoma and Gamma-Delta T-Large Granular Lymphocytic Leukemia in a Patient with Rheumatoid Arthritis.

Gorodetskiy VR et al.

Cancer Management and Research, 2020

Structural Implications of STAT3 and STAT5 SH2 Domain Mutations.

de Araujo ED et al.

Cancers, 2019

Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma.

Chan JY et al.

Blood Cancer Journal, 2018

Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.

Menon MP et al.

The American Journal of Surgical Pathology, 2015

The Ying and Yang of STAT3 in Human Disease.

Vogel TP et al.

Journal of Clinical Immunology, 2015

Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Creixell P et al.

Cell, 2015

26388441 (PubMed )
Supplement: mmc9.xlsx › COSMIC_v67MappedToEnsembl_right

The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia.

Rajala HL et al.

Haematologica, 2015

STAT3 in Cancer-Friend or Foe?

Zhang HF et al.

Cancers, 2014

Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations.

Rajala HL et al.

Annals of Medicine, 2014

Somatic STAT3 mutations in large granular lymphocytic leukemia.

Koskela HL et al.

The New England Journal of Medicine, 2012

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."