Varaico: Literature-Extracted Genetic Variants

Gene:STAT3
Variant:p.Y657F
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STAT3

NM_139276.3:p.Y657F

Associated Papers

Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers.

Kasembeli MM et al.

Blood, 2023

36240433 (PubMed )
Supplement: BLOOD_BLD-2021-015330-mmc1.pdf

The role of understudied post-translational modifications for the behavior and function of Signal Transducer and Activator of Transcription 3.

Diallo M et al.

The Febs Journal, 2022

Phospho-Ser727 triggers a multistep inactivation of STAT3 by rapid dissociation of pY705-SH2 through C-terminal tail modulation.

Yang J et al.

International Immunology, 2020

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity.

Mori R et al.

Scientific Reports, 2017

Unique structural determinants for Stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744.

Shao H et al.

Journal of Immunology (baltimore, Md. : 1950), 2006

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."