Varaico: Literature-Extracted Genetic Variants

Gene:STAT3
Variant:p.Y640F
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STAT3

NM_139276.3:p.Y640F

Associated Papers

Diagnostic criteria for NK cell large granular lymphocyte leukemia: validation through a multicentric international study.

Pastoret C et al.

Blood Advances, 2026

Targeted deep sequencing identifies mosaicism in patients with immune dysregulation.

Schmitz EG et al.

The Journal of Allergy and Clinical Immunology, 2026

Dynamics of clonal hematopoiesis and cellular responses to stress-induced toxicity in autologous stem cell transplantation.

Stein CM et al.

Leukemia, 2026

41419602 (PubMed )
Supplement: 41375_2025_2823_MOESM2_ESM.xlsx › putative_variants

Genomic profiles of myelodysplastic neoplasm with bone marrow eosinophilia or basophilia: Inflammatory drivers and DNA damage response.

Jung Y et al.

Leukemia Research, 2026

Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations.

Colin-Leitzinger C et al.

Human Genomics, 2025

41331781 (PubMed )
Supplement: 40246_2025_847_MOESM1_ESM.pdf

Clinical Validation of a Rapid Automated Lymphoma Next-Generation Sequencing Panel.

Krigstein M et al.

Annals of Laboratory Medicine, 2025

41277019 (PubMed )
Supplement: ALM3692_Supple1.xlsx › Reference_Standard

Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome.

Tefft K et al.

The Journal of Clinical Investigation, 2025

Genomics of T-Cell Lymphomas With CD30/CD15 Co-Expression: Comparison With Anaplastic Large-Cell Lymphoma, ALK-Negative.

de Castro JVA et al.

The American Journal of Surgical Pathology, 2025

Lymphocytic Variant Hypereosinophilic Syndrome With Extensive Mucocutaneous Involvement Successfully Treated With Ruxolitinib.

Montivero AR et al.

American Journal of Hematology, 2025

Somatic mutation and selection at population scale.

Lawson ARJ et al.

Nature, 2025

41062696 (PubMed )
Supplement: 41586_2025_9584_MOESM1_ESM.pdf

Genomic profiling in hepatocellular carcinoma: a real-world retrospective analysis.

Salani F et al.

Esmo Open, 2025

41167083 (PubMed )
Supplement: mmc4.xlsx › Table_S10B

Transcriptomic landscape of CD8+ and CD4 + T-LGL leukemia revealed the distinct impact of STAT3 and STAT5B activating mutations.

Calabretto G et al.

Leukemia, 2025

Distinct characteristics of lymphoid and myeloid clonal hematopoiesis in World Trade Center first responders.

Esai Selvan M et al.

Medrxiv : the Preprint Server for Health Sciences, 2025

40778119 (PubMed )
Supplement: media-2.pdf

Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes.

Hiitola E et al.

Science Advances, 2025

40305610 (PubMed )
Supplement: sciadv.adt9846_tables_s1_to_s13.zip › adt9846_tables_s1_to_s13.xlsx › S3

Inborn errors of immunity underlie clonal T cell expansions in large granular lymphocyte leukemia.

Bravo-Perez C et al.

The Journal of Clinical Investigation, 2025

40309770 (PubMed )
Supplement: jci-135-184431-s106.xlsx › Table_S5

Efficacy and influencing factors of immunosuppressive therapy for pure red cell aplasia: meta-analysis and systematic review.

Yusup M et al.

Annals of Hematology, 2025

Clinical features and outcomes in large granular lymphocyte leukemia - associated pure red cell aplasia with STAT3 mutation.

Liu X et al.

Annals of Hematology, 2025

Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgrounds.

Colin-Leitzinger C et al.

Medrxiv : the Preprint Server for Health Sciences, 2025

40166537 (PubMed )
Supplement: media-1.pdf

Mutational heterogeneities in STAT3 and clonal hematopoiesis-related genes in acquired pure red cell aplasia.

Kawakami T et al.

Annals of Hematology, 2025

40202536 (PubMed )
Supplement: 277_2025_6356_MOESM3_ESM.xlsx › S4

T-cell lymphoproliferative disorder with a STAT3 mutation causing a lymphocytic variant of hypereosinophilic-like syndrome without eosinophilia.

Marinelli L et al.

Journal of Hematopathology, 2025

T-cell Large Granular Lymphocytic Leukemia with a STAT3 Mutation Successfully Treated with Cord Blood Transplantation.

Tokunaga Y et al.

Internal Medicine (tokyo, Japan), 2025

Functional validation of a novel STAT3 'variant of unknown significance' identifies a new case of STAT3 GOF syndrome and reveals broad immune cell defects.

Mackie J et al.

Clinical and Experimental Immunology, 2025

The genomic and clinical consequences of replacing procarbazine with dacarbazine in escalated BEACOPP for Hodgkin lymphoma: a retrospective, observational study.

Santarsieri A et al.

The Lancet. Oncology, 2025

Functional apoptosis profiling reveals vulnerabilities in T-cell large granular lymphocytic leukemia.

Shumilov E et al.

Annals of Hematology, 2025

ALK-negative anaplastic large cell lymphoma with TP53 mutation developing during the administration of baricitinib for atopic dermatitis - A case report.

Kawai H et al.

Journal of Clinical and Experimental Hematopathology : Jceh, 2025

HSP and CD279 gene expression as candidate biomarkers in symptomatic LGLL patients.

Talarico G et al.

Discover Oncology, 2024

Distinctive genomic features of human T-lymphotropic virus type 1-related adult T-cell leukemia-lymphoma in Western populations.

Myers CS et al.

Haematologica, 2024

39113648 (PubMed )
Supplement: 2024_285233_MYERS_TABLES_SUPPL.xlsx › S1_COSMIC_Variants

Integrated Clinical Genotype-Phenotype Characteristics of STAT3-Mutated Myeloid Neoplasms.

Ye MT et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Investigation of the mutations in the genes involved in Janus kinase/signal transducer and activator of transcription pathway in canine large cell gastrointestinal lymphoma.

Tsuruta T et al.

The Journal of Veterinary Medical Science, 2024

Unidirectional association of clonal hematopoiesis with atherosclerosis development.

Díez-Díez M et al.

Nature Medicine, 2024

39215150 (PubMed )
Supplement: 41591_2024_3213_MOESM3_ESM.xlsx › Supplementary_Table_2

Study of sex-biased differences in genomic profiles in East Asian hepatocellular carcinoma.

Huang CY et al.

Discover Oncology, 2024

Clinical Validation of a Targeted Next-Generation Sequencing Panel for Lymphoid Malignancies.

Artymiuk CJ et al.

The Journal of Molecular Diagnostics : Jmd, 2024

Somatic mutations associate with clonal expansion of CD8+ T cells.

Lundgren S et al.

Science Advances, 2024

EBV+ nodal T/NK-cell lymphoma associated with clonal hematopoiesis and structural variations of the viral genome.

Kato S et al.

Blood Advances, 2024

38429084 (PubMed )
Supplement: BLOODA_ADV-2023-012019-mmc1.pdf

Fibroblast-derived interleukin-6 exacerbates adverse cardiac remodeling after myocardial infarction.

Li H et al.

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2024

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."