Associated Papers
Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development.
Lee HK et al.
Journal of Mammary Gland Biology and Neoplasia, 2025
Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation.
Lin JX et al.
Nature Communications, 2024
A novel intramolecular negative regulation of mouse Jak3 activity by tyrosine 820.
Sekine Y et al.
International Immunology, 2022
Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization.
Hsiao WY et al.
Plos One, 2015
PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis.
Berger A et al.
Leukemia, 2014
Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.
Chaix A et al.
The Journal of Biological Chemistry, 2011
A regulating role of the JAK2 FERM domain in hyperactivation of JAK2(V617F).
Zhao L et al.
The Biochemical Journal, 2010
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.
Hosui A et al.
The Journal of Experimental Medicine, 2009
Constitutive nuclear import of latent and activated STAT5a by its coiled coil domain.
Iyer J et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2008
Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain.
Weaver AM et al.
Molecular Endocrinology (baltimore, Md.), 2006
CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity.
Peng B et al.
Molecular Endocrinology (baltimore, Md.), 2002
Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity.
Park SH et al.
Molecular Endocrinology (baltimore, Md.), 2001
Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells.
Mahajan S et al.
The Journal of Biological Chemistry, 2001
Constitutive activation of STAT5 by a point mutation in the SH2 domain.
Ariyoshi K et al.
The Journal of Biological Chemistry, 2000
Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation.
Liu KD et al.
Current Biology : Cb, 1997
Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.
Lin JX et al.
The Journal of Biological Chemistry, 1996