Associated Papers
Mosaic variants in KRAS and STAT5B associated with a mixed phenotype of 2 acquired errors of immunity.
Forkgen J et al.
The Journal of Allergy and Clinical Immunology, 2026
Divergent molecular pathways drive monomorphic epitheliotropic and enteropathy-associated intestinal T-cell lymphoma.
Vallois D et al.
Leukemia, 2026
Genomic profiles of myelodysplastic neoplasm with bone marrow eosinophilia or basophilia: Inflammatory drivers and DNA damage response.
Jung Y et al.
Leukemia Research, 2026
Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases.
Grün S et al.
The Journal of Allergy and Clinical Immunology, 2025
Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism.
Lee HK et al.
Biorxiv : the Preprint Server for Biology, 2025
Clinical experience of using integrated whole genome and transcriptome sequencing as a framework for pediatric and adolescent acute myeloid leukemia diagnosis and risk assessment.
Voss RK et al.
Leukemia, 2025
Clinical Validation of a Rapid Automated Lymphoma Next-Generation Sequencing Panel.
Krigstein M et al.
Annals of Laboratory Medicine, 2025
Clinical features, mutational landscape and their prognostic impact in Chinese paediatric patients with T-cell lymphoblastic lymphoma.
Li Y et al.
British Journal of Haematology, 2025
The Prognostic Role of STAT5B Across Cancer Types and Comparative Analysis with STAT5A: A Systematic Review.
Maninang C et al.
Biomolecules, 2025
Transcriptomic landscape of CD8+ and CD4 + T-LGL leukemia revealed the distinct impact of STAT3 and STAT5B activating mutations.
Calabretto G et al.
Leukemia, 2025
Mosaic STAT5B gain-of-function associated with demyelinating disease and autoimmunity.
Schmitt EG et al.
Journal of Human Immunity, 2025
Crescentic glomerulonephritis associated with NK-large granular lymphocytic leukemia: A case report.
Luo Z et al.
Medicine, 2025
STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.
Lee HK et al.
Life Science Alliance, 2025
Mutation-induced rigidity in the Fyn SH2 domain enhances pY-binding affinity at the cost of peptide specificity.
Deng L et al.
Physical Chemistry Chemical Physics : Pccp, 2025
Inborn Errors of Immunity in Apoptosis.
Makkoukdji N et al.
Frontiers in Bioscience (landmark Edition), 2025
Inborn errors of immunity underlie clonal T cell expansions in large granular lymphocyte leukemia.
Bravo-Perez C et al.
The Journal of Clinical Investigation, 2025
Single-cell sequencing reveals shared clonal signatures in nonmalignant B and tumor cells in T-prolymphocytic leukemia.
Hesselager C et al.
Blood Neoplasia, 2025
Somatic mosaicism in genetic errors of immunity.
Cooper MA
The Journal of Allergy and Clinical Immunology, 2025
Novel ETV6::RAPGEF6 fusion gene in chronic eosinophilic leukemia: compiling evidence on the role of IL3 overexpression in tumorigenesis.
Iberti M et al.
Annals of Hematology, 2025
Mutational heterogeneities in STAT3 and clonal hematopoiesis-related genes in acquired pure red cell aplasia.
Kawakami T et al.
Annals of Hematology, 2025
Spotlight on amino acid changing mutations in the JAK-STAT pathway: from disease-specific mutation to general mutation databases.
Hoffmann M et al.
Scientific Reports, 2025
T-cell Large Granular Lymphocytic Leukemia with a STAT3 Mutation Successfully Treated with Cord Blood Transplantation.
Tokunaga Y et al.
Internal Medicine (tokyo, Japan), 2025
JAK-STAT signaling pathway, immunodeficiency, inflammation, immune dysregulation, and inborn errors of immunity.
Samra S et al.
The Journal of Allergy and Clinical Immunology, 2025
The structural influence of the oncogenic driver mutation N642H in the STAT5B SH2 domain.
Haas-Neill L et al.
Protein Science : a Publication of the Protein Society, 2025
Recurrent Missense Driver STAT5B N642H Mutation in Children Transiting into Adolescence, with Acute Lymphoid Leukemia and its In silico Inhibition.
Yasmin R et al.
Anti-cancer Agents in Medicinal Chemistry, 2025
T-cell prolymphocytic leukemia, a case report and review of the literature.
GONZáLEZ-RODRíGUEZ LM et al.
Oncology Research, 2025
Asymptomatic T prolymphocytic leukemia: case report and literature review.
Honorato Junior LFB et al.
Einstein (sao Paulo, Brazil), 2025
JAK/STAT in human diseases: a common axis in immunodeficiencies and hematological disorders.
Djidjik R et al.
Frontiers in Immunology, 2025
STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.
Lee HK et al.
Biorxiv : the Preprint Server for Biology, 2024
Eosinophilia with STAT5BN642H Mutation: A Heterogeneous Entity with Overlapping Morphological Features and Poor Outcome
Shashidhar V et al.
Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology, 2024
Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma.
Pölöske D et al.
Hemasphere, 2024
Investigation of the mutations in the genes involved in Janus kinase/signal transducer and activator of transcription pathway in canine large cell gastrointestinal lymphoma.
Tsuruta T et al.
The Journal of Veterinary Medical Science, 2024
GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway.
Ikeuchi H et al.
Oncogene, 2024
PIM1 is a potential therapeutic target for the leukemogenic effects mediated by JAK/STAT pathway mutations in T-ALL/LBL.
Lahera A et al.
Npj Precision Oncology, 2024
Oncogenic and immunological targets for matched therapy of pediatric blood cancer patients: Dutch iTHER study experience.
Boer JM et al.
Hemasphere, 2024
STAT5B mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia.
Yin CC et al.
Haematologica, 2024
Involvement of the JAK-STAT pathway in the molecular landscape of tyrosine kinase fusion-negative hypereosinophilic syndromes: A nationwide CEREO study.
Groh M et al.
American Journal of Hematology, 2024
Broad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations.
Kandarpa M et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
Suske T et al.
The Journal of Clinical Investigation, 2024
Clinicopathological and molecular genetic alterations in monomorphic-epitheliotropic intestinal T-cell lymphoma of the small intestine.
Zhou B et al.
European Journal of Medical Research, 2024