Associated Papers
Mosaic variants in KRAS and STAT5B associated with a mixed phenotype of 2 acquired errors of immunity.
Forkgen J et al.
The Journal of Allergy and Clinical Immunology, 2026
Transcriptomic landscape of CD8+ and CD4 + T-LGL leukemia revealed the distinct impact of STAT3 and STAT5B activating mutations.
Calabretto G et al.
Leukemia, 2025
Mosaic STAT5B gain-of-function associated with demyelinating disease and autoimmunity.
Schmitt EG et al.
Journal of Human Immunity, 2025
Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes.
Hiitola E et al.
Science Advances, 2025
The structural influence of the oncogenic driver mutation N642H in the STAT5B SH2 domain.
Haas-Neill L et al.
Protein Science : a Publication of the Protein Society, 2025
JAK/STAT in human diseases: a common axis in immunodeficiencies and hematological disorders.
Djidjik R et al.
Frontiers in Immunology, 2025
Eosinophilia with STAT5BN642H Mutation: A Heterogeneous Entity with Overlapping Morphological Features and Poor Outcome
Shashidhar V et al.
Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology, 2024
PIM1 is a potential therapeutic target for the leukemogenic effects mediated by JAK/STAT pathway mutations in T-ALL/LBL.
Lahera A et al.
Npj Precision Oncology, 2024
Somatic mutations associate with clonal expansion of CD8+ T cells.
Lundgren S et al.
Science Advances, 2024
STAT5B mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia.
Yin CC et al.
Haematologica, 2024
Pro-inflammatory cells sustain leukemic clonal expansion in T-cell large granular lymphocyte leukemia.
Vicenzetto C et al.
Haematologica, 2024
TP53 mutations identify high-risk events for peripheral T-cell lymphoma treated with CHOP-based chemotherapy.
Johnson WT et al.
Blood Advances, 2023
Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome.
Veloza L et al.
Haematologica, 2023
Activating STAT5B mutations can cause both primary hypereosinophilia and lymphocyte-variant hypereosinophilia.
Umrau K et al.
Leukemia & Lymphoma, 2023
Targeted panel sequencing in the routine diagnosis of mature T- and NK-cell lymphomas: report of 128 cases from two German reference centers.
Böck J et al.
Frontiers in Oncology, 2023
Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia.
Bhattacharya D et al.
Blood Cancer Journal, 2022
Expanding diagnostic criteria: Multiorgan T-Cell/myeloid mixed phenotype acute leukemia with t(v;11q23) KMT2A-rearrangement successfully treated by allogeneic stem cell transplant.
Syed S et al.
Leukemia Research Reports, 2022
Mutation signatures of pediatric acute myeloid leukemia and normal blood progenitors associated with differential patient outcomes.
Brandsma AM et al.
Blood Cancer Discovery, 2021
STAT3 and STAT5B mutations have unique distribution in T-cell large granular lymphocyte proliferations and advanced myeloid neoplasms.
Qu S et al.
Leukemia & Lymphoma, 2021
Somatic mutations and T-cell clonality in patients with immunodeficiency.
Savola P et al.
Haematologica, 2020
JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL.
Wahnschaffe L et al.
Cancers, 2019
Structural Implications of STAT3 and STAT5 SH2 Domain Mutations.
de Araujo ED et al.
Cancers, 2019
STAT5A and STAT5B-Twins with Different Personalities in Hematopoiesis and Leukemia.
Maurer B et al.
Cancers, 2019
Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma.
Tiacci E et al.
Blood, 2018
Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling.
Andersson EI et al.
Leukemia, 2018
Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
Schrader A et al.
Nature Communications, 2018
Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.
Moffitt AB et al.
The Journal of Experimental Medicine, 2017
The Genetic Basis of Hepatosplenic T-cell Lymphoma.
McKinney M et al.
Cancer Discovery, 2017
Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia.
Richter-Pechańska P et al.
Blood Cancer Journal, 2017
Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.
Roberti A et al.
Nature Communications, 2016
Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia.
López C et al.
British Journal of Haematology, 2016
Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia.
Kiel MJ et al.
Blood, 2014