Associated Papers
An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.
Li FX et al.
Cell Insight, 2026
STING: a multifaced player in cellular homeostasis.
Song K et al.
Human Molecular Genetics, 2025
Cysteine allostery and autoinhibition govern human STING oligomer functionality.
Chan R et al.
Nature Chemical Biology, 2025
Cell biological insights into human STING variants.
Koide S et al.
Cell Structure and Function, 2025
Mosaic TMEM173 gene mutation R284S leading to STING-associated vasculopathy with onset in infancy (SAVI).
Yang Z et al.
International Journal of Dermatology, 2025
IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1.
Venkatraman R et al.
Iscience, 2024
A rare manifestation of STING-associated vasculopathy with onset in infancy: a case report.
Weidler S et al.
Pediatric Rheumatology Online Journal, 2024
Membrane traffic governs the STING inflammatory signalling.
Taguchi T
Journal of Biochemistry, 2023
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M et al.
Nature Communications, 2023
Case report: JAK1/2 inhibition with baricitinib in the treatment of STING-associated vasculopathy with onset in infancy.
Wu J et al.
Pediatric Rheumatology Online Journal, 2023
Regulation of cGAS and STING signaling during inflammation and infection.
Chauvin SD et al.
The Journal of Biological Chemistry, 2023
SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.
Ji Y et al.
Nature Cell Biology, 2023
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling.
Gentili M et al.
Nature Communications, 2023
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation.
Xie Z et al.
Cell Discovery, 2022
Use of Tofacitinib for infant-onset STING-associated vasculopathy: A case report from China.
Shen D et al.
Medicine, 2022
UNC13D inhibits STING signaling by attenuating its oligomerization on the endoplasmic reticulum.
Song P et al.
Embo Reports, 2022
Phenotypic spectrum in recessive STING-associated vasculopathy with onset in infancy: Four novel cases and analysis of previously reported cases.
Wan R et al.
Frontiers in Immunology, 2022
The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation.
Shindo R et al.
Frontiers in Cell and Developmental Biology, 2022
Molecular mechanisms of phenotypic variability in monogenic autoinflammatory diseases.
Aksentijevich I et al.
Nature Reviews. Rheumatology, 2021
STING-Mediated Lung Inflammation and Beyond.
Frémond ML et al.
Journal of Clinical Immunology, 2021
Functional Asplenia and Specific Polysaccharide Antibody Deficiency in a Girl with SAVI.
Bijker EM et al.
Journal of Clinical Immunology, 2021
STING-associated vasculopathy with onset in infancy: a familial case series report and literature review.
Wang Y et al.
Annals of Translational Medicine, 2021
Case Report: Novel SAVI-Causing Variants in STING1 Expand the Clinical Disease Spectrum and Suggest a Refined Model of STING Activation.
Lin B et al.
Frontiers in Immunology, 2021
A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI).
Lin B et al.
The Journal of Allergy and Clinical Immunology, 2020
Familial Interstitial Lung Disease Caused by Mutation of the STING1 Gene.
Li J et al.
Frontiers in Pediatrics, 2020
Adult-Onset ANCA-Associated Vasculitis in SAVI: Extension of the Phenotypic Spectrum, Case Report and Review of the Literature.
Staels F et al.
Frontiers in Immunology, 2020
Stimulator of Interferon Genes-Associated Vasculopathy With Onset in Infancy: A Systematic Review of Case Reports.
Dai Y et al.
Frontiers in Pediatrics, 2020
The Challenge of Diagnosing SAVI: Case Studies.
Cao Y et al.
Pediatric Allergy, Immunology, and Pulmonology, 2019
STING modulators: Predictive significance in drug discovery.
Cui X et al.
European Journal of Medicinal Chemistry, 2019
STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Ergun SL et al.
Cell, 2019
STING palmitoylation as a therapeutic target.
Hansen AL et al.
Cellular & Molecular Immunology, 2019
Novel TMEM173 Mutation and the Role of Disease Modifying Alleles.
Keskitalo S et al.
Frontiers in Immunology, 2019
Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING.
Konno H et al.
Cell Reports, 2018
A Mutation Outside the Dimerization Domain Causing Atypical STING-Associated Vasculopathy With Onset in Infancy.
Saldanha RG et al.
Frontiers in Immunology, 2018