Associated Papers
An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.
Li FX et al.
Cell Insight, 2026
STING: a multifaced player in cellular homeostasis.
Song K et al.
Human Molecular Genetics, 2025
A novel STING1-activating mutation is identified in a patient with childhood-onset systemic lupus erythematosus.
Li T et al.
Clinical Immunology (orlando, Fla.), 2025
Cell biological insights into human STING variants.
Koide S et al.
Cell Structure and Function, 2025
Mosaic TMEM173 gene mutation R284S leading to STING-associated vasculopathy with onset in infancy (SAVI).
Yang Z et al.
International Journal of Dermatology, 2025
A novel STING variant triggers endothelial toxicity and SAVI disease.
Valeri E et al.
The Journal of Experimental Medicine, 2024
Membrane traffic governs the STING inflammatory signalling.
Taguchi T
Journal of Biochemistry, 2023
Case report: JAK1/2 inhibition with baricitinib in the treatment of STING-associated vasculopathy with onset in infancy.
Wu J et al.
Pediatric Rheumatology Online Journal, 2023
Treatment of STING-associated vasculopathy with onset in infancy in patients carrying a novel mutation in the TMEM173 gene with the JAK3-inhibitor tofacitinib.
Tokgun PE et al.
Archives of Rheumatology, 2023
Use of Tofacitinib for infant-onset STING-associated vasculopathy: A case report from China.
Shen D et al.
Medicine, 2022
Intracellular Sensing of DNA in Autoinflammation and Autoimmunity.
MacLauchlan S et al.
Arthritis & Rheumatology (hoboken, N.j.), 2022
MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention.
Zhong B et al.
Current Opinion in Immunology, 2022
Hereditary Systemic Autoinflammatory Diseases: Therapeutic Stratification.
Kul Cinar O et al.
Frontiers in Pediatrics, 2022
Post-Translational Modifications of STING: A Potential Therapeutic Target.
Kang J et al.
Frontiers in Immunology, 2022
The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation.
Shindo R et al.
Frontiers in Cell and Developmental Biology, 2022
Molecular mechanisms of phenotypic variability in monogenic autoinflammatory diseases.
Aksentijevich I et al.
Nature Reviews. Rheumatology, 2021
Stimulator of Interferon Genes-associated Vasculopathy with an Onset in Infancy Diagnosed after the Development of Atypical Pulmonary Lesions During Treatment as Juvenile Idiopathic Arthritis.
Nishida T et al.
Internal Medicine (tokyo, Japan), 2021
STING-Mediated Lung Inflammation and Beyond.
Frémond ML et al.
Journal of Clinical Immunology, 2021
STING-associated vasculopathy with onset in infancy: a familial case series report and literature review.
Wang Y et al.
Annals of Translational Medicine, 2021
Case Report: Novel SAVI-Causing Variants in STING1 Expand the Clinical Disease Spectrum and Suggest a Refined Model of STING Activation.
Lin B et al.
Frontiers in Immunology, 2021
STING Operation at the ER/Golgi Interface.
Taguchi T et al.
Frontiers in Immunology, 2021
Familial Interstitial Lung Disease Caused by Mutation of the STING1 Gene.
Li J et al.
Frontiers in Pediatrics, 2020
Adult-Onset ANCA-Associated Vasculitis in SAVI: Extension of the Phenotypic Spectrum, Case Report and Review of the Literature.
Staels F et al.
Frontiers in Immunology, 2020
Stimulator of Interferon Genes-Associated Vasculopathy With Onset in Infancy: A Systematic Review of Case Reports.
Dai Y et al.
Frontiers in Pediatrics, 2020
The Challenge of Diagnosing SAVI: Case Studies.
Cao Y et al.
Pediatric Allergy, Immunology, and Pulmonology, 2019
STING palmitoylation as a therapeutic target.
Hansen AL et al.
Cellular & Molecular Immunology, 2019
Severe combined immunodeficiency in stimulator of interferon genes (STING) V154M/wild-type mice.
Bouis D et al.
The Journal of Allergy and Clinical Immunology, 2019
TMEM173 variants and potential importance to human biology and disease.
Patel S et al.
Genes and Immunity, 2019
G3BP1 promotes DNA binding and activation of cGAS.
Liu ZS et al.
Nature Immunology, 2019
Novel TMEM173 Mutation and the Role of Disease Modifying Alleles.
Keskitalo S et al.
Frontiers in Immunology, 2019
The binding of TBK1 to STING requires exocytic membrane traffic from the ER.
Ogawa E et al.
Biochemical and Biophysical Research Communications, 2018
Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING.
Konno H et al.
Cell Reports, 2018
A Mutation Outside the Dimerization Domain Causing Atypical STING-Associated Vasculopathy With Onset in Infancy.
Saldanha RG et al.
Frontiers in Immunology, 2018
Type I interferon-mediated autoinflammation due to DNase II deficiency.
Rodero MP et al.
Nature Communications, 2017
Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling.
Melki I et al.
The Journal of Allergy and Clinical Immunology, 2017
Genomics, Biology, and Human Illness: Advances in the Monogenic Autoinflammatory Diseases.
Oda H et al.
Rheumatic Diseases Clinics of North America, 2017
STING-associated vasculopathy with onset in infancy (SAVI) presenting with skin lesions.
Latour-Álvarez I et al.
Pediatric Dermatology, 0