Associated Papers
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation.
Xie Z et al.
Cell Discovery, 2022
Protein-Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory.
Vavřina Z et al.
Biochemistry, 2021
STING modulators: Predictive significance in drug discovery.
Cui X et al.
European Journal of Medicinal Chemistry, 2019
TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages.
Li Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists.
Liu B et al.
Antiviral Research, 2017
Single Mutations Reshape the Structural Correlation Network of the DMXAA-Human STING Complex.
Che X et al.
The Journal of Physical Chemistry. B, 2017
Regulating STING in health and disease.
Li Y et al.
Journal of Inflammation (london, England), 2017
Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.
Gao P et al.
Cell Reports, 2014
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.
Gao P et al.
Cell, 2013
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