Associated Papers
An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.
Li FX et al.
Cell Insight, 2026
A Novel Heterozygous STING1 Point Mutation Causes Pulmonary Arterial Hypertension in Children: A Case Report.
Chen L et al.
Pediatric Pulmonology, 2026
Identification of a Novel Heterozygous Variant c.497g>a (p.gly166glu) in Exon 5 of the Sting1 Gene as the Causative Factor of Sting-Associated Vasculopathy With Onset in Infancy (SAVI): A Case Report.
Mansilla-Polo M et al.
Actas Dermo-sifiliograficas, 2025
STING: a multifaced player in cellular homeostasis.
Song K et al.
Human Molecular Genetics, 2025
STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches.
Nan Y et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2025
Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice.
Freytag D et al.
Embo Molecular Medicine, 2025
Severe interstitial lung disease as the first manifestation of a STING1 variant in a familial case.
Kang Z et al.
Immunologic Research, 2025
A novel STING1-activating mutation is identified in a patient with childhood-onset systemic lupus erythematosus.
Li T et al.
Clinical Immunology (orlando, Fla.), 2025
The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis.
Gül A et al.
Nature Reviews. Rheumatology, 2025
Cell biological insights into human STING variants.
Koide S et al.
Cell Structure and Function, 2025
ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation.
Poddar S et al.
Cell, 2025
A Novel Treatment of STING-Associated Vasculopathy With Onset in Infancy.
Solarska-Rydz K et al.
Pediatric Pulmonology, 2025
Mosaic TMEM173 gene mutation R284S leading to STING-associated vasculopathy with onset in infancy (SAVI).
Yang Z et al.
International Journal of Dermatology, 2025
Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus.
Goldbach-Mansky R et al.
Nature Reviews. Rheumatology, 2025
Response to two Janus kinase inhibitors in a boy with SAVI during 2-year follow-up: case report and literature review.
Chen Y et al.
Frontiers in Immunology, 2025
Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform 'cold' tumors into 'hot' tumors.
Ying X et al.
Molecular Cancer, 2024
Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.
Gentili M et al.
Cell Systems, 2024
ZC3HAV1 facilitates STING activation and enhances inflammation.
Qin D et al.
Communications Biology, 2024
Normalized Interferon Signatures and Clinical Improvements by IFNAR1 Blocking Antibody (Anifrolumab) in Patients with Type I Interferonopathies.
Kretzschmar G et al.
Journal of Clinical Immunology, 2024
Advances in the prerequisite and consequence of STING downstream signalosomes.
Lu X et al.
Medical Review (2021), 2024
The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
Aybar-Torres AA et al.
Elife, 2024
A novel STING variant triggers endothelial toxicity and SAVI disease.
Valeri E et al.
The Journal of Experimental Medicine, 2024
Inheritance of STING mosaicism in two half-siblings.
de Becdelièvre A et al.
Journal of Clinical Immunology, 2024
The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
Aybar-Torres A et al.
Biorxiv : the Preprint Server for Biology, 2024
Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
Mutlu M et al.
Nature Communications, 2024
Structural Evaluations of a Selective Human STINGA230 Agonist and Its Use in Macrophage Immunotherapies.
Tang Z et al.
Acs Medicinal Chemistry Letters, 2024
Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.
Gentili M et al.
Biorxiv : the Preprint Server for Biology, 2024
STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges.
Yang K et al.
Neuron, 2024
Heterozygous mutations in the C-terminal domain of COPA underlie a complex autoinflammatory syndrome.
Delafontaine S et al.
The Journal of Clinical Investigation, 2024
Single-cell RNA-sequencing of PBMCs from SAVI patients reveals disease-associated monocytes with elevated integrated stress response.
de Cevins C et al.
Cell Reports. Medicine, 2023
Membrane traffic governs the STING inflammatory signalling.
Taguchi T
Journal of Biochemistry, 2023
Regulation of STING activity in DNA sensing by ISG15 modification.
Lin C et al.
Cell Reports, 2023
The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties.
Froechlich G et al.
Scientific Reports, 2023
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M et al.
Nature Communications, 2023
Case report: JAK1/2 inhibition with baricitinib in the treatment of STING-associated vasculopathy with onset in infancy.
Wu J et al.
Pediatric Rheumatology Online Journal, 2023
Monogenic lupus: Tracing the therapeutic implications from single gene mutations.
Jia X et al.
Clinical Immunology (orlando, Fla.), 2023
Treatment of STING-associated vasculopathy with onset in infancy in patients carrying a novel mutation in the TMEM173 gene with the JAK3-inhibitor tofacitinib.
Tokgun PE et al.
Archives of Rheumatology, 2023
Regulation of cGAS and STING signaling during inflammation and infection.
Chauvin SD et al.
The Journal of Biological Chemistry, 2023
Termination of STING responses is mediated via ESCRT-dependent degradation.
Balka KR et al.
The Embo Journal, 2023
STING trafficking as a new dimension of immune signaling.
Jeltema D et al.
The Journal of Experimental Medicine, 2023
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling.
Gentili M et al.
Nature Communications, 2023
Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases.
Pan J et al.
Zoological Research, 2023
Vasculitis and vasculopathy associated with inborn errors of immunity: an overview.
Federici S et al.
Frontiers in Pediatrics, 2023
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy.
Zhang Z et al.
Signal Transduction and Targeted Therapy, 2022