Associated Papers
An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.
Li FX et al.
Cell Insight, 2026
Lung-only involvement in STING-associated vasculopathy with onset in infancy: a diagnostic pitfall in the absence of cutaneous vasculitis.
Kisla Ekinci RM et al.
Zeitschrift Fur Rheumatologie, 2026
STING: a multifaced player in cellular homeostasis.
Song K et al.
Human Molecular Genetics, 2025
Cholesterol sensing by the SCAP-FAM134B complex regulates ER-phagy and STING innate immunity.
Li B et al.
Nature Cell Biology, 2025
Sustained Interferon Signature Suppression With Anifrolumab in a Patient With STING-Associated Vasculopathy with Onset in Infancy Refractory to JAK Inhibitor and Dazukibart Therapy.
Alehashemi S et al.
Arthritis & Rheumatology (hoboken, N.j.), 2025
ArfGAP2 deficiency ameliorates autoinflammation by regulating STING signaling and proton channel activity.
Zhang M et al.
Acta Biochimica Et Biophysica Sinica, 2025
A novel STING1-activating mutation is identified in a patient with childhood-onset systemic lupus erythematosus.
Li T et al.
Clinical Immunology (orlando, Fla.), 2025
Cell biological insights into human STING variants.
Koide S et al.
Cell Structure and Function, 2025
ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation.
Poddar S et al.
Cell, 2025
Mosaic TMEM173 gene mutation R284S leading to STING-associated vasculopathy with onset in infancy (SAVI).
Yang Z et al.
International Journal of Dermatology, 2025
Response to two Janus kinase inhibitors in a boy with SAVI during 2-year follow-up: case report and literature review.
Chen Y et al.
Frontiers in Immunology, 2025
Advances in the prerequisite and consequence of STING downstream signalosomes.
Lu X et al.
Medical Review (2021), 2024
Decoding Missense Variants by Incorporating Phase Separation via Machine Learning.
Feng M et al.
Nature Communications, 2024
The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
Aybar-Torres AA et al.
Elife, 2024
A novel STING variant triggers endothelial toxicity and SAVI disease.
Valeri E et al.
The Journal of Experimental Medicine, 2024
STING trafficking activates MAPK-CREB signaling to trigger regulatory T cell differentiation.
Lin W et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
Aybar-Torres A et al.
Biorxiv : the Preprint Server for Biology, 2024
Computational insights into the conformational transition of STING: Mechanistic, energetic considerations, and the influence of crucial mutations.
Li Z et al.
Journal of Molecular Graphics & Modelling, 2024
Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
Mutlu M et al.
Nature Communications, 2024
STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges.
Yang K et al.
Neuron, 2024
5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation.
Temizoz B et al.
Frontiers in Immunology, 2024
Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis.
Zhang R et al.
Immunity, 2023
Membrane traffic governs the STING inflammatory signalling.
Taguchi T
Journal of Biochemistry, 2023
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M et al.
Nature Communications, 2023
Case report: JAK1/2 inhibition with baricitinib in the treatment of STING-associated vasculopathy with onset in infancy.
Wu J et al.
Pediatric Rheumatology Online Journal, 2023
Treatment of STING-associated vasculopathy with onset in infancy in patients carrying a novel mutation in the TMEM173 gene with the JAK3-inhibitor tofacitinib.
Tokgun PE et al.
Archives of Rheumatology, 2023
Regulation of cGAS and STING signaling during inflammation and infection.
Chauvin SD et al.
The Journal of Biological Chemistry, 2023
Termination of STING responses is mediated via ESCRT-dependent degradation.
Balka KR et al.
The Embo Journal, 2023
STING trafficking as a new dimension of immune signaling.
Jeltema D et al.
The Journal of Experimental Medicine, 2023
Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases.
Pan J et al.
Zoological Research, 2023
Use of Tofacitinib for infant-onset STING-associated vasculopathy: A case report from China.
Shen D et al.
Medicine, 2022
Human induced pluripotent stem cells generated from STING-associated vasculopathy with onset in infancy (SAVI) patients with a heterozygous mutation in the STING gene.
Mehta A et al.
Stem Cell Research, 2022
Intracellular Sensing of DNA in Autoinflammation and Autoimmunity.
MacLauchlan S et al.
Arthritis & Rheumatology (hoboken, N.j.), 2022
MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention.
Zhong B et al.
Current Opinion in Immunology, 2022
Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes.
Luo WW et al.
Nature Communications, 2022
How Fragile We Are: Influence of Stimulator of Interferon Genes (STING) Variants on Pathogen Recognition and Immune Response Efficiency.
Morere J et al.
Journal of Chemical Information and Modeling, 2022
Prevalence of monogenic disease in paediatric patients with a predominant respiratory phenotype.
Dai D et al.
Archives of Disease in Childhood, 2022
The transmembrane endoplasmic reticulum-associated E3 ubiquitin ligase TRIM13 restrains the pathogenic-DNA-triggered inflammatory response.
Li X et al.
Science Advances, 2022
Lung Inflammation in STING-Associated Vasculopathy with Onset in Infancy (SAVI).
David C et al.
Cells, 2022
The relationship between defects in DNA repair genes and autoinflammatory diseases.
Kivanc D et al.
Rheumatology International, 2022
Janus Kinase Inhibitors in the Treatment of Type I Interferonopathies: A Case Series From a Single Center in China.
Li W et al.
Frontiers in Immunology, 2022
Post-Translational Modifications of STING: A Potential Therapeutic Target.
Kang J et al.
Frontiers in Immunology, 2022
Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus.
Wobma H et al.
Frontiers in Immunology, 2022
The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration.
Ottone OK et al.
Frontiers in Immunology, 2022
Primary immunodeficiencies in Bulgaria - achievements and challenges of the PID National Expert Center.
Naumova E et al.
Frontiers in Immunology, 2022
The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation.
Shindo R et al.
Frontiers in Cell and Developmental Biology, 2022
The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Decout A et al.
Nature Reviews. Immunology, 2021