Associated Papers
An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.
Li FX et al.
Cell Insight, 2026
PBLD Orchestrates the STING-Mediated Antiviral Immune Response and Autoimmune Diseases.
Hou P et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2026
TAX1BP1-dependent autophagic degradation of STING1 impairs anti-tumor immunity.
Zhang R et al.
Autophagy, 2025
Porcine deltacoronavirus nonstructural protein 2 inhibits type I and III IFN production by targeting STING for degradation.
Liu X et al.
Veterinary Research, 2024
Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
Mutlu M et al.
Nature Communications, 2024
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling.
Gentili M et al.
Nature Communications, 2023
A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis.
Zhang D et al.
Nature Cell Biology, 2022
The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway.
Zhang L et al.
Plos Pathogens, 2018
Ubiquitination of STING at lysine 224 controls IRF3 activation.
Ni G et al.
Science Immunology, 2017
STING recognition of cytoplasmic DNA instigates cellular defense.
Abe T et al.
Molecular Cell, 2013
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding.
Ouyang S et al.
Immunity, 2012
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