Associated Papers
An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.
Li FX et al.
Cell Insight, 2026
Discovery of the thieno[2,3-b][1,4]thiazin-2(3H)-one STING inhibitors.
Han L et al.
Bioorganic & Medicinal Chemistry, 2026
STING: a multifaced player in cellular homeostasis.
Song K et al.
Human Molecular Genetics, 2025
STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches.
Nan Y et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2025
A novel STING1-activating mutation is identified in a patient with childhood-onset systemic lupus erythematosus.
Li T et al.
Clinical Immunology (orlando, Fla.), 2025
Cell biological insights into human STING variants.
Koide S et al.
Cell Structure and Function, 2025
ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation.
Poddar S et al.
Cell, 2025
Decoding Missense Variants by Incorporating Phase Separation via Machine Learning.
Feng M et al.
Nature Communications, 2024
A novel STING variant triggers endothelial toxicity and SAVI disease.
Valeri E et al.
The Journal of Experimental Medicine, 2024
Computational insights into the conformational transition of STING: Mechanistic, energetic considerations, and the influence of crucial mutations.
Li Z et al.
Journal of Molecular Graphics & Modelling, 2024
Membrane traffic governs the STING inflammatory signalling.
Taguchi T
Journal of Biochemistry, 2023
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M et al.
Nature Communications, 2023
Treatment of STING-associated vasculopathy with onset in infancy in patients carrying a novel mutation in the TMEM173 gene with the JAK3-inhibitor tofacitinib.
Tokgun PE et al.
Archives of Rheumatology, 2023
Strategies involving STING pathway activation for cancer immunotherapy: Mechanism and agonists.
Pan X et al.
Biochemical Pharmacology, 2023
The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus.
Kong L et al.
Cell Reports, 2023
Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases.
Pan J et al.
Zoological Research, 2023
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation.
Xie Z et al.
Cell Discovery, 2022
Use of Tofacitinib for infant-onset STING-associated vasculopathy: A case report from China.
Shen D et al.
Medicine, 2022
Human induced pluripotent stem cells generated from STING-associated vasculopathy with onset in infancy (SAVI) patients with a heterozygous mutation in the STING gene.
Mehta A et al.
Stem Cell Research, 2022
Intracellular Sensing of DNA in Autoinflammation and Autoimmunity.
MacLauchlan S et al.
Arthritis & Rheumatology (hoboken, N.j.), 2022
MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention.
Zhong B et al.
Current Opinion in Immunology, 2022
Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes.
Luo WW et al.
Nature Communications, 2022
How Fragile We Are: Influence of Stimulator of Interferon Genes (STING) Variants on Pathogen Recognition and Immune Response Efficiency.
Morere J et al.
Journal of Chemical Information and Modeling, 2022
The transmembrane endoplasmic reticulum-associated E3 ubiquitin ligase TRIM13 restrains the pathogenic-DNA-triggered inflammatory response.
Li X et al.
Science Advances, 2022
Lung Inflammation in STING-Associated Vasculopathy with Onset in Infancy (SAVI).
David C et al.
Cells, 2022
The relationship between defects in DNA repair genes and autoinflammatory diseases.
Kivanc D et al.
Rheumatology International, 2022
Post-Translational Modifications of STING: A Potential Therapeutic Target.
Kang J et al.
Frontiers in Immunology, 2022
Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus.
Wobma H et al.
Frontiers in Immunology, 2022
The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation.
Shindo R et al.
Frontiers in Cell and Developmental Biology, 2022
Stimulator of Interferon Genes-associated Vasculopathy with an Onset in Infancy Diagnosed after the Development of Atypical Pulmonary Lesions During Treatment as Juvenile Idiopathic Arthritis.
Nishida T et al.
Internal Medicine (tokyo, Japan), 2021
STING-Mediated Lung Inflammation and Beyond.
Frémond ML et al.
Journal of Clinical Immunology, 2021
The STING phase-separator suppresses innate immune signalling.
Yu X et al.
Nature Cell Biology, 2021
STING-associated vasculopathy with onset in infancy: a familial case series report and literature review.
Wang Y et al.
Annals of Translational Medicine, 2021
Case Report: Novel SAVI-Causing Variants in STING1 Expand the Clinical Disease Spectrum and Suggest a Refined Model of STING Activation.
Lin B et al.
Frontiers in Immunology, 2021
STING Operation at the ER/Golgi Interface.
Taguchi T et al.
Frontiers in Immunology, 2021
STING Signaling and Sterile Inflammation.
Couillin I et al.
Frontiers in Immunology, 2021
A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI).
Lin B et al.
The Journal of Allergy and Clinical Immunology, 2020
Case Report: Acute Thrombotic Microangiopathy in a Patient with STING-Associated Vasculopathy with Onset in Infancy (SAVI).
Ma M et al.
Journal of Clinical Immunology, 2020
The cGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease.
Ma R et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2020
Toward a better understanding of type I interferonopathies: a brief summary, update and beyond.
Yu ZX et al.
World Journal of Pediatrics : Wjp, 2020
APOL1-Associated Collapsing Focal Segmental Glomerulosclerosis in a Patient With Stimulator of Interferon Genes (STING)-Associated Vasculopathy With Onset in Infancy (SAVI).
Abid Q et al.
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 2020
Familial Interstitial Lung Disease Caused by Mutation of the STING1 Gene.
Li J et al.
Frontiers in Pediatrics, 2020
Adult-Onset ANCA-Associated Vasculitis in SAVI: Extension of the Phenotypic Spectrum, Case Report and Review of the Literature.
Staels F et al.
Frontiers in Immunology, 2020
The Challenge of Diagnosing SAVI: Case Studies.
Cao Y et al.
Pediatric Allergy, Immunology, and Pulmonology, 2019
STING modulators: Predictive significance in drug discovery.
Cui X et al.
European Journal of Medicinal Chemistry, 2019
STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Ergun SL et al.
Cell, 2019
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Shang G et al.
Nature, 2019