Varaico: Literature-Extracted Genetic Variants

Gene:STK11
Variant:p.D5H
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STK11

NM_000455.5:p.D5H

Associated Papers

Genomic Profile of Non-Small Cell Lung Cancer in a Spanish Cohort: A 2-Year Descriptive Study Using Next-Generation Sequencing.

Carnero-Gregorio M et al.

Genes, 2026

Integrative proteomic characterization of human lung adenocarcinoma with KRAS G12 mutations reveals molecular pathogenesis.

Shi X et al.

Journal of Advanced Research, 2025

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers.

Li C et al.

Nature Communications, 2025

40316540 (PubMed )
Supplement: 41467_2025_58753_MOESM1_ESM.pdf

Targeting KRAS in cancer.

Singhal A et al.

Nature Medicine, 2024

Unveiling the role of KRAS in tumor immune microenvironment.

Xu M et al.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2024

Effects of KRAS Genetic Interactions on Outcomes in Cancers of the Lung, Pancreas, and Colorectum.

Grabski IN et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2024

The rapidly changing field of predictive biomarkers of non-small cell lung cancer.

Tóth LJ et al.

Pathology Oncology Research : Por, 2024

Clinical perspectives on the value of testing for STK11 and KEAP1 mutations in advanced NSCLC.

Shiller M et al.

Frontiers in Oncology, 2024

39703851 (PubMed )
Supplement: DataSheet2.xlsx › Supplemental_data

Analysis of the benefit of anti-PD-1 monotherapy according to NGS-diagnosed genetic alterations in patients with non-small cell lung cancer.

De Saint Basile H et al.

Exploration of Targeted Anti-tumor Therapy, 2024

Baseline mutational profiles of patients with carcinoma of unknown primary origin enrolled in the CUPISCO study.

Westphalen CB et al.

Esmo Open, 2023

37922692 (PubMed )
Supplement: mmc1.docx

Prevalence of oncogenic driver mutations in Hispanics/Latin patients with lung cancer. A systematic review and meta-analysis.

Parra-Medina R et al.

Lung Cancer (amsterdam, Netherlands), 2023

ARID1A Mutation from Targeted Next-Generation Sequencing Predicts Primary Resistance to Gemcitabine and Cisplatin Chemotherapy in Advanced Biliary Tract Cancer.

Lee SH et al.

Cancer Research and Treatment, 2023

Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers.

Huffman KE et al.

Frontiers in Oncology, 2023

Comprehensive pan-cancer genomic landscape of KRAS altered cancers and real-world outcomes in solid tumors.

Lee JK et al.

Npj Precision Oncology, 2022

36494601 (PubMed )
Supplement: 41698_2022_334_MOESM1_ESM.pdf

Molecular Biology and Therapeutic Perspectives for K-Ras Mutant Non-Small Cell Lung Cancers.

Cekani E et al.

Cancers, 2022

STK11/LKB1 Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic Impact.

Pons-Tostivint E et al.

Cells, 2021

Antitumor efficacy of XPO1 inhibitor Selinexor in KRAS-mutant lung adenocarcinoma patient-derived xenografts.

Rosen JC et al.

Translational Oncology, 2021

Phase 1, pharmacogenomic, dose-expansion study of pegargiminase plus pemetrexed and cisplatin in patients with ASS1-deficient non-squamous non-small cell lung cancer.

Szlosarek PW et al.

Cancer Medicine, 2021

Outcomes and prognostic contributors in patients with KRAS mutated non-small cell pulmonary adenocarcinomas: a single institution experience.

Burns EA et al.

Journal of Thoracic Disease, 2021

Mutational landscape of multiple primary lung cancers and its correlation with non-intrinsic risk factors.

Izumi M et al.

Scientific Reports, 2021

Comprehensive genomic profiling of Brazilian non-small cell lung cancer patients (GBOT 0118/LACOG0418).

Mascarenhas E et al.

Thoracic Cancer, 2021

Characterization With KRAS Mutant Is a Critical Determinant in Immunotherapy and Other Multiple Therapies for Non-Small Cell Lung Cancer.

Shen M et al.

Frontiers in Oncology, 2021

KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples.

Loong HH et al.

Translational Lung Cancer Research, 2020

Comprehensive genomic profile of cholangiocarcinomas in China.

Tian W et al.

Oncology Letters, 2020

Mutational Diversity of Lung Cancer and Associated Lymph Nodes. An Exploratory Prospective Study of 4 Resected cIIIA-N2.

Legras A et al.

Pathology Oncology Research : Por, 2019

Different prognostic impact of STK11 mutations in non-squamous non-small-cell lung cancer.

Pécuchet N et al.

Oncotarget, 2017

26625312 (PubMed )
Supplement: oncotarget-08-23831-s002.xls › Feuil1

Clinical and Molecular Characteristics of NF1-Mutant Lung Cancer.

Redig AJ et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2016

KRAS-G12C mutation is associated with poor outcome in surgically resected lung adenocarcinoma.

Nadal E et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2014

Inferring primary tumor sites from mutation spectra: a meta-analysis of histology-specific aberrations in cancer-derived cell lines.

Dietlein F et al.

Human Molecular Genetics, 2014

LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition.

Mahoney CL et al.

British Journal of Cancer, 2009

Genomic landscape and actionable mutations of brain metastases derived from non-small cell lung cancer: A systematic review.

Andrews LJ et al.

Neuro-oncology Advances, 0

38130901 (PubMed )
Supplement: vdad145_suppl_supplementary_data.xlsx › Individual_data
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."