Varaico: Literature-Extracted Genetic Variants

Gene:STK11
Variant:p.K48R
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STK11

NM_000455.5:p.K48R

Associated Papers

Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.

Son SM et al.

Neuron, 2025

Impact of protein and small molecule interactions on kinase conformations.

Kugler V et al.

Elife, 2024

FBXO22 mediates polyubiquitination and inactivation of LKB1 to promote lung cancer cell growth.

Zhu XN et al.

Cell Death & Disease, 2019

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer.

Zubiete-Franco I et al.

Ebiomedicine, 2019

Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress.

Lee SW et al.

Molecular Cell, 2015

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.

Lan F et al.

The Journal of Biological Chemistry, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."