Associated Papers
LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors.
Trelford CB et al.
Cell Communication and Signaling : Ccs, 2024
Landscape of potential germline pathogenic variants in select cancer susceptibility genes in patients with adult-type ovarian granulosa cell tumors.
Summey RM et al.
Cancer Medicine, 2024
[The course and clinical manifestations of Peutz-Jeghers syndrome in the Russian population].
Savelyeva ТA et al.
Terapevticheskii Arkhiv, 2023
Evaluation of AlphaFold structure-based protein stability prediction on missense variations in cancer.
Keskin Karakoyun H et al.
Frontiers in Genetics, 2023
Effects of Peutz-Jeghers syndrome (PJS) causing missense mutations L67P, L182P, G242V and R297S on the structural dynamics of LKB1 (Liver kinase B1) protein.
Rungsung I et al.
Journal of Biomolecular Structure & Dynamics, 2019
Frequency and spectrum of cancers in the Peutz-Jeghers syndrome.
Hearle N et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2006
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
Mehenni H et al.
Human Molecular Genetics, 2005
KinMutBase: a registry of disease-causing mutations in protein kinase domains.
Ortutay C et al.
Human Mutation, 2005
Genotype-phenotype correlations in Peutz-Jeghers syndrome.
Amos CI et al.
Journal of Medical Genetics, 2004
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
Lim W et al.
British Journal of Cancer, 2003
LKB1, a protein kinase regulating cell proliferation and polarity.
Boudeau J et al.
Febs Letters, 2003
Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma.
Olschwang S et al.
Journal of Medical Genetics, 2001
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
Collins SP et al.
The Biochemical Journal, 2000
The molecular basis and clinical aspects of Peutz-Jeghers syndrome.
Hemminki A
Cellular and Molecular Life Sciences : Cmls, 1999
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.
Ylikorkala A et al.
Human Molecular Genetics, 1999
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.
Mehenni H et al.
American Journal of Human Genetics, 1998