Varaico: Literature-Extracted Genetic Variants

Gene:STK11
Variant:p.K78M
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STK11

NM_000455.5:p.K78M

Associated Papers

The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin.

Shimada T et al.

International Journal of Molecular Sciences, 2022

Corrigendum to "Re-expression of LKB1 in LKB1-mutant EKVX cells leads to resistance to paclitaxel through the up-regulation of MDR1 expression" [Lung Cancer 88/2 (2015) 131-138].

Mao K et al.

Lung Cancer (amsterdam, Netherlands), 2021

Phenformin enhances the therapeutic effect of selumetinib in KRAS-mutant non-small cell lung cancer irrespective of LKB1 status.

Zhang J et al.

Oncotarget, 2017

Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity.

Zhang S et al.

Cell Death and Differentiation, 2016

LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.

Xu X et al.

Molecular and Cellular Biology, 2013

STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells.

Eggers CM et al.

The Journal of Biological Chemistry, 2012

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

Jacob LS et al.

Science Signaling, 2011

Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC).

Kim DW et al.

Molecular Endocrinology (baltimore, Md.), 2007

LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation.

Zeng PY et al.

Cancer Research, 2006

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.

Karuman P et al.

Molecular Cell, 2001

An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation.

Liu WK et al.

Journal of Biomedical Science, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."