Associated Papers
Insights into targeting LKB1 in tumorigenesis.
Trelford CB et al.
Genes & Diseases, 2025
Impact of protein and small molecule interactions on kinase conformations.
Kugler V et al.
Elife, 2024
[The course and clinical manifestations of Peutz-Jeghers syndrome in the Russian population].
Savelyeva ТA et al.
Terapevticheskii Arkhiv, 2023
Pan-cancer whole-genome analyses of metastatic solid tumours.
Priestley P et al.
Nature, 2019
Targeted next-generation sequencing of well-differentiated rectal, gastric, and appendiceal neuroendocrine tumors to identify potential targets.
Park HY et al.
Human Pathology, 2019
Clinical manifestations and STK11 germline mutations in Taiwanese patients with Peutz-Jeghers syndrome.
Chiang JM et al.
Asian Journal of Surgery, 2018
wKinMut-2: Identification and Interpretation of Pathogenic Variants in Human Protein Kinases.
Vazquez M et al.
Human Mutation, 2016
Novel and recurrent mutations of STK11 gene in six Chinese cases with Peutz-Jeghers syndrome.
Dai L et al.
Digestive Diseases and Sciences, 2014
STK11 domain XI mutations: candidate genetic drivers leading to the development of dysplastic polyps in Peutz-Jeghers syndrome.
Wang Z et al.
Human Mutation, 2014
Possible involvement of LKB1-AMPK signaling in non-homologous end joining.
Ui A et al.
Oncogene, 2014
Germline mutation analysis of STK11 gene using direct sequencing and multiplex ligation-dependent probe amplification assay in Korean children with Peutz-Jeghers syndrome.
Yang HR et al.
Digestive Diseases and Sciences, 2010
Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates.
de Leng WW et al.
Clinical Genetics, 2007
Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome.
Mehenni H et al.
Digestive Diseases and Sciences, 2007
The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1.
Setogawa T et al.
Biochemical and Biophysical Research Communications, 2006
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
Mehenni H et al.
Human Molecular Genetics, 2005
STK11 genotyping and cancer risk in Peutz-Jeghers syndrome.
Schumacher V et al.
Journal of Medical Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling.
Lin-Marq N et al.
Molecular Genetics and Genomics : Mgg, 2005
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
Lim W et al.
British Journal of Cancer, 2003
LKB1, a protein kinase regulating cell proliferation and polarity.
Boudeau J et al.
Febs Letters, 2003
Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.
Boudeau J et al.
Human Mutation, 2003
Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).
Tiainen M et al.
Human Molecular Genetics, 2002
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
Collins SP et al.
The Biochemical Journal, 2000
The molecular basis and clinical aspects of Peutz-Jeghers syndrome.
Hemminki A
Cellular and Molecular Life Sciences : Cmls, 1999
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.
Mehenni H et al.
American Journal of Human Genetics, 1998