Associated Papers
Impact of protein and small molecule interactions on kinase conformations.
Kugler V et al.
Elife, 2024
The Tumor Suppressor Kinase LKB1: Metabolic Nexus.
Bourouh M et al.
Frontiers in Cell and Developmental Biology, 2022
Genomic profiles of Indonesian colorectal cancer patients.
Abdullah M et al.
F1000research, 2022
STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation.
Granado-Martínez P et al.
Communications Biology, 2020
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer.
Hermanova I et al.
The Journal of Experimental Medicine, 2020
Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.
Hutchinson LD et al.
Cell Death & Disease, 2020
Deletion of endothelial cell-specific liver kinase B1 increases angiogenesis and tumor growth via vascular endothelial growth factor.
Zhang W et al.
Oncogene, 2017
LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons.
Kwon SK et al.
Plos Biology, 2016
Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.
Okon IS et al.
The Journal of Clinical Investigation, 2014
Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells.
Okon IS et al.
The Journal of Biological Chemistry, 2014
The LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell lines.
Mack HI et al.
Virology, 2013
Primary cilia regulate mTORC1 activity and cell size through Lkb1.
Boehlke C et al.
Nature Cell Biology, 2010
LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity.
Xu X et al.
Bmc Cell Biology, 2010
LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain.
Deguchi A et al.
The Journal of Biological Chemistry, 2010
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
Zeqiraj E et al.
Science (new York, N.y.), 2009
Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis.
Xie Z et al.
Molecular and Cellular Biology, 2009
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.
Zheng B et al.
Molecular Cell, 2009
Characterization of an alternative splice variant of LKB1.
Denison FC et al.
The Journal of Biological Chemistry, 2009
C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.
Fogarty S et al.
The Journal of Biological Chemistry, 2009
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.
Lan F et al.
The Journal of Biological Chemistry, 2008
Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells.
Song P et al.
The Journal of Biological Chemistry, 2008
Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.
Xie Z et al.
Circulation, 2008
Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling.
Kojima Y et al.
The Journal of Biological Chemistry, 2007
LKB1 catalytically deficient mutants enhance cyclin D1 expression.
Scott KD et al.
Cancer Research, 2007
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.
Barnes AP et al.
Cell, 2007
LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells.
Imai K et al.
Biochemical and Biophysical Research Communications, 2006
LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer.
Upadhyay S et al.
Cancer Research, 2006
Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.
Jaleel M et al.
Febs Letters, 2005
Analysis of the LKB1-STRAD-MO25 complex.
Boudeau J et al.
Journal of Cell Science, 2004
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.
Corradetti MN et al.
Genes & Development, 2004
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
Lizcano JM et al.
The Embo Journal, 2004
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.
Woods A et al.
Current Biology : Cb, 2003
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
Boudeau J et al.
The Embo Journal, 2003
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.
Spicer J et al.
Oncogene, 2003
Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.
Boudeau J et al.
Human Mutation, 2003
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
Hawley SA et al.
Journal of Biology, 2003
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.
Sanchez-Cespedes M et al.
Cancer Research, 2002
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.
Sapkota GP et al.
The Biochemical Journal, 2002
LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.
Smith DP et al.
Human Molecular Genetics, 2001