Varaico: Literature-Extracted Genetic Variants

Gene:STK11
Variant:p.R297S
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STK11

NM_000455.5:p.R297S

Associated Papers

Ovarian Sex Cord Tumor With Annular Tubules (SCTAT) Harbor Recurrent Copy Number Alterations, Including Monosomy 22.

Leader AM et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2025

Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition.

Zhang T et al.

Biorxiv : the Preprint Server for Biology, 2025

40161734 (PubMed )
Supplement: media-2.xlsx › Supplementary_Table_4

Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers.

Chen Y et al.

Human Genetics, 2025

Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers.

Chen Y et al.

Research Square, 2024

LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors.

Trelford CB et al.

Cell Communication and Signaling : Ccs, 2024

Unravelling the role of PLK1 in tumorigenesis by revealing the mutational landscape of colorectal and lung cancer with PLK1 mutations.

Wang S et al.

Journal of Cellular and Molecular Medicine, 2024

38887977 (PubMed )
Supplement: JCMM-28-e18497-s002.xlsx › Sheet1

High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer.

Palafox M et al.

Nature Communications, 2022

36071033 (PubMed )
Supplement: 41467_2022_32828_MOESM4_ESM.xlsx › Fig_2A_and_Table_S4

Plasma Genotyping at the Time of Diagnostic Tissue Biopsy Decreases Time-to-Treatment in Patients With Advanced NSCLC-Results From a Prospective Pilot Study.

Thompson JC et al.

Jto Clinical and Research Reports, 2022

35392653 (PubMed )
Supplement: mmc3.xlsx › All_data

Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers.

Donnelly LL et al.

Carcinogenesis, 2021

CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer.

Gutiontov SI et al.

Scientific Reports, 2021

34625620 (PubMed )
Supplement: 41598_2021_99524_MOESM2_ESM.xlsx › Mutations

Effects of Peutz-Jeghers syndrome (PJS) causing missense mutations L67P, L182P, G242V and R297S on the structural dynamics of LKB1 (Liver kinase B1) protein.

Rungsung I et al.

Journal of Biomolecular Structure & Dynamics, 2019

A lesson from a reported pathogenic variant in Peutz-Jeghers syndrome: a case report.

Tan H et al.

Familial Cancer, 2017

STK11 domain XI mutations: candidate genetic drivers leading to the development of dysplastic polyps in Peutz-Jeghers syndrome.

Wang Z et al.

Human Mutation, 2014

Frequency and spectrum of cancers in the Peutz-Jeghers syndrome.

Hearle N et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2006

Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.

Lim W et al.

British Journal of Cancer, 2003

LKB1, a protein kinase regulating cell proliferation and polarity.

Boudeau J et al.

Febs Letters, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."