Associated Papers
Comprehensively Testing the Function of Missense Variation in the STK11 Tumour Suppressor.
Zimmerman D et al.
Biorxiv : the Preprint Server for Biology, 2025
Insights into targeting LKB1 in tumorigenesis.
Trelford CB et al.
Genes & Diseases, 2025
Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers.
Chen Y et al.
Human Genetics, 2025
Impact of protein and small molecule interactions on kinase conformations.
Kugler V et al.
Elife, 2024
The genomic landscape of lung cancer in never-smokers from the Women's Health Initiative.
Moorthi S et al.
Jci Insight, 2024
Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers.
Chen Y et al.
Research Square, 2024
LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors.
Trelford CB et al.
Cell Communication and Signaling : Ccs, 2024
Development, testing and validation of a targeted NGS-panel for the detection of actionable mutations in lung cancer (NSCLC) using anchored multiplex PCR technology in a multicentric setting.
Kumbrink J et al.
Pathology Oncology Research : Por, 2024
CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer.
Gutiontov SI et al.
Scientific Reports, 2021
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.
Vichas A et al.
Nature Communications, 2021
Prediction of Deleterious Non-synonymous SNPs of Human STK11 Gene by Combining Algorithms, Molecular Docking, and Molecular Dynamics Simulation.
Islam MJ et al.
Scientific Reports, 2019
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden.
Chalmers ZR et al.
Genome Medicine, 2017
STK11 domain XI mutations: candidate genetic drivers leading to the development of dysplastic polyps in Peutz-Jeghers syndrome.
Wang Z et al.
Human Mutation, 2014
[Clinical characteristics and mutation analysis of the LKB1 gene in a Peutz-Jeghers syndrome pedigree].
Pan J et al.
Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics, 2013
Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates.
de Leng WW et al.
Clinical Genetics, 2007
Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome.
Mehenni H et al.
Digestive Diseases and Sciences, 2007
Frequency and spectrum of cancers in the Peutz-Jeghers syndrome.
Hearle N et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2006
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
Mehenni H et al.
Human Molecular Genetics, 2005
STK11 genotyping and cancer risk in Peutz-Jeghers syndrome.
Schumacher V et al.
Journal of Medical Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Schumacher V et al.
Human Genetics, 2005
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
Lim W et al.
British Journal of Cancer, 2003
LKB1, a protein kinase regulating cell proliferation and polarity.
Boudeau J et al.
Febs Letters, 2003
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
Collins SP et al.
The Biochemical Journal, 2000
The molecular basis and clinical aspects of Peutz-Jeghers syndrome.
Hemminki A
Cellular and Molecular Life Sciences : Cmls, 1999
Identification of a novel mRNA species of the LKB1/STK11 Peutz-Jeghers serine/threonine kinase.
Churchman M et al.
Dna Sequence : the Journal of Dna Sequencing and Mapping, 1999
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.
Mehenni H et al.
American Journal of Human Genetics, 1998