Varaico: Literature-Extracted Genetic Variants

Gene:STK11
Variant:p.P324L
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STK11

NM_000455.5:p.P324L

Associated Papers

Longitudinal Glioma Monitoring via Cerebrospinal Fluid Cell-Free DNA.

Riviere-Cazaux C et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2025

39715486 (PubMed )
Supplement: ccr-24-1814_supplemental_table_2_suppts2.xlsx › Sheet1

Analysis of Sequence and Copy Number Variants in Canadian Patient Cohort With Familial Cancer Syndromes Using a Unique Next Generation Sequencing Based Approach.

Bhai P et al.

Frontiers in Genetics, 2021

34326862 (PubMed )
Supplement: Data_Sheet_1.zip › Supplementary_files › Supplementary_Table_S4.xlsx › Every_test

LKB1 mutations are not associated with the efficacy of first-line and second-line chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC): a post hoc analysis of the TAILOR trial.

Vernieri C et al.

Esmo Open, 2020

Workflow for the Implementation of Precision Genomics in Healthcare.

Mehandziska S et al.

Frontiers in Genetics, 2020

32695137 (PubMed )
Supplement: Data_Sheet_2.XLSX › Actionable_conditions

The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors.

Stehr H et al.

Molecular Cancer, 2011

21575214 (PubMed )
Supplement: 1476-4598-10-54-S3.XLS › mutations.txt

Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.

Zang ZJ et al.

Cancer Research, 2011

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.

Zeqiraj E et al.

Science (new York, N.y.), 2009

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.

Towler MC et al.

The Biochemical Journal, 2008

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

Forcet C et al.

Human Molecular Genetics, 2005

Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.

Lim W et al.

British Journal of Cancer, 2003

LKB1, a protein kinase regulating cell proliferation and polarity.

Boudeau J et al.

Febs Letters, 2003

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

Sapkota GP et al.

The Biochemical Journal, 2002

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."