Associated Papers
Identification of residues critical for the extension of Munc18-1 domain 3a.
Wang X et al.
Bmc Biology, 2023
On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release.
Rizo J et al.
Febs Open Bio, 2022
SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex.
Stepien KP et al.
Science Advances, 2022
Molecular Mechanisms Underlying Neurotransmitter Release.
Rizo J
Annual Review of Biophysics, 2022
Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association.
Jiao J et al.
Elife, 2018
Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly.
Meijer M et al.
The Embo Journal, 2018
Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
Sitarska E et al.
Elife, 2017
Extension of Helix 12 in Munc18-1 Induces Vesicle Priming.
Munch AS et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2016
A pivotal role for pro-335 in balancing the dual functions of Munc18-1 domain-3a in regulated exocytosis.
Han GA et al.
The Journal of Biological Chemistry, 2014
An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly.
Parisotto D et al.
The Journal of Biological Chemistry, 2014
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