Associated Papers
Accurate affinity models for SH2 domains from peptide binding assays and free-energy regression.
Gagoski D et al.
Protein Science : a Publication of the Protein Society, 2025
41088778 (PubMed )
Supplement: PRO-34-e70317-s008.xlsx › _S6_-_PTMVar_-_Grb2
Novel SYK Variant Causes Enhanced SYK Autophosphorylation and PI3K Activation in an Antibody-Deficient Patient.
Edwards ESJ et al.
Journal of Clinical Immunology, 2025
Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression.
Gagoski D et al.
Biorxiv : the Preprint Server for Biology, 2025
39764007 (PubMed )
Supplement: media-1.xlsx › _S6_-_PTMVar_-_Grb2
Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants.
Capener JL et al.
Biorxiv : the Preprint Server for Biology, 2024
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.
Wang L et al.
Nature Genetics, 2021
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