Varaico: Literature-Extracted Genetic Variants

Gene:SYK
Variant:p.K402R
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SYK

NM_003177.7:p.K402R

Associated Papers

A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane.

Loureiro CA et al.

Cellular and Molecular Life Sciences : Cmls, 2020

The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex.

Kassouf T et al.

Cancers, 2019

Tyrosine phosphorylation modulates cell surface expression of chloride cotransporters NKCC2 and KCC3.

Loureiro CA et al.

Archives of Biochemistry and Biophysics, 2019

Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk.

Bhardwaj D et al.

Journal of Cellular Biochemistry, 2018

The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease.

Dierks C et al.

Cancer Research, 2010

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.

Pechloff K et al.

The Journal of Experimental Medicine, 2010

Phosphatidylinositol-3-kinase-dependent phosphorylation of SLP-76 by the lymphoma-associated ITK-SYK fusion-protein.

Hussain A et al.

Biochemical and Biophysical Research Communications, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."