Associated Papers
Novel SYK Variant Causes Enhanced SYK Autophosphorylation and PI3K Activation in an Antibody-Deficient Patient.
Edwards ESJ et al.
Journal of Clinical Immunology, 2025
Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants.
Capener JL et al.
Biorxiv : the Preprint Server for Biology, 2024
The evolutionary impact of childhood cancer on the human gene pool.
Stoltze UK et al.
Nature Communications, 2024
38424437 (PubMed )
Supplement: 41467_2024_45975_MOESM4_ESM.xlsx › Supplementary_Data_15
Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer.
Wagener R et al.
European Journal of Human Genetics : Ejhg, 2021
33840814 (PubMed )
Supplement: 41431_2021_878_MOESM2_ESM.xlsx › Table_S3
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.
Wang L et al.
Nature Genetics, 2021
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