Associated Papers
Understanding liquid-liquid phase separation through TDP-43: fundamental principles, subcellular compartmentalisation, and role of solid inclusion formation.
Bigi A et al.
Genome Biology, 2026
Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns.
Pérez-Berlanga M et al.
The Embo Journal, 2023
Biophysical evaluation of the oligomerization and conformational properties of the N-terminal domain of TDP-43.
Herrera MG et al.
Archives of Biochemistry and Biophysics, 2023
Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies.
Ni J et al.
Molecular Psychiatry, 2023
Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD.
Wood A et al.
International Journal of Molecular Sciences, 2021
Insight into the Folding and Dimerization Mechanisms of the N-Terminal Domain from Human TDP-43.
Vivoli-Vega M et al.
International Journal of Molecular Sciences, 2020
TDP-43 and FUS-structural insights into RNA recognition and self-association.
Loughlin FE et al.
Current Opinion in Structural Biology, 2019
The N-terminal dimerization is required for TDP-43 splicing activity.
Jiang LL et al.
Scientific Reports, 2017
Structural insights into the multi-determinant aggregation of TDP-43 in motor neuron-like cells.
Bozzo F et al.
Neurobiology of Disease, 2016
Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation.
Chiang CH et al.
Scientific Reports, 2016
The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids.
Kuo PH et al.
Nucleic Acids Research, 2014
4-Hydroxynonenal induces persistent insolubilization of TDP-43 and alters its intracellular localization.
Kabuta C et al.
Biochemical and Biophysical Research Communications, 0
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