Associated Papers
TDP-43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models.
Pir GJ et al.
The Febs Journal, 2026
Inhibiting glycogen synthase kinase 3 suppresses TDP-43-mediated neurotoxicity in a caspase-dependent manner.
White MA et al.
Research Square, 2025
TDP-43 and ER Stress in Neurodegeneration: Friends or Foes?
de Mena L et al.
Frontiers in Molecular Neuroscience, 2021
Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.
Wobst HJ et al.
Plos One, 2017
Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation.
Chiang CH et al.
Scientific Reports, 2016
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.
Li Q et al.
Nature Communications, 2015
TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.
Suzuki H et al.
The Journal of Biological Chemistry, 2011
Neurotoxic effects of TDP-43 overexpression in C. elegans.
Ash PE et al.
Human Molecular Genetics, 2010
Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration.
Gendron TF et al.
Neuropathology and Applied Neurobiology, 2010
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Dormann D et al.
Journal of Neurochemistry, 2009
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.
Zhang YJ et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2007
Select a paper to view details