Varaico: Literature-Extracted Genetic Variants

Gene:TARDBP
Variant:p.D174A
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TARDBP

NM_007375.4:p.D174A

Associated Papers

Dynamics of binding interactions of TDP-43 and RNA: An equally weighted multiscale elastic network model study.

Deng X et al.

Proteins, 2022

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation.

Rengifo-Gonzalez JC et al.

Elife, 2021

Exploring the molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43 using molecular dynamics simulation and free energy calculation.

Sun H et al.

Journal of Computational Chemistry, 2021

The proteinopathy of D169G and K263E mutants at the RNA Recognition Motif (RRM) domain of tar DNA-binding protein (tdp43) causing neurological disorders: A computational study.

Bhandare VV et al.

Journal of Biomolecular Structure & Dynamics, 2018

The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.

Li Q et al.

Nature Communications, 2015

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43.

Lukavsky PJ et al.

Nature Structural & Molecular Biology, 2013

FTD and ALS: a tale of two diseases.

Ferrari R et al.

Current Alzheimer Research, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."