Associated Papers
Uncovering Intermolecular Interactions Driving the Liquid-Liquid Phase Separation of the TDP-43 Low-Complexity Domain via Atomistic Dimerization Simulations.
Tang H et al.
Journal of Chemical Information and Modeling, 2024
TDP-43 Amyloid Fibril Formation via Phase Separation-Related and -Unrelated Pathways.
Lin PH et al.
Acs Chemical Neuroscience, 2024
Pathological C-terminal phosphomimetic substitutions alter the mechanism of liquid-liquid phase separation of TDP-43 low complexity domain.
Haider R et al.
Protein Science : a Publication of the Protein Society, 2024
Decoding Missense Variants by Incorporating Phase Separation via Machine Learning.
Feng M et al.
Nature Communications, 2024
39333476 (PubMed )
Supplement: 41467_2024_52580_MOESM4_ESM.xlsx › impact_ps_mutations
Pathological C-terminal phosphomimetic substitutions alter the mechanism of liquid-liquid phase separation of TDP-43 low complexity domain.
Haider R et al.
Biorxiv : the Preprint Server for Biology, 2024
Role of Triggers on the Structural and Functional Facets of TAR DNA-binding Protein 43.
Camilus N et al.
Neuroscience, 2023
Different Intermolecular Interactions Drive Nonpathogenic Liquid-Liquid Phase Separation and Potentially Pathogenic Fibril Formation by TDP-43.
Zeng YT et al.
International Journal of Molecular Sciences, 2022
The Different Faces of the TDP-43 Low-Complexity Domain: The Formation of Liquid Droplets and Amyloid Fibrils.
Chien HM et al.
International Journal of Molecular Sciences, 2021
A protein assembly mediates Xist localization and gene silencing.
Pandya-Jones A et al.
Nature, 2020
TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues.
Li HR et al.
The Journal of Biological Chemistry, 2018
The physical forces mediating self-association and phase-separation in the C-terminal domain of TDP-43.
Li HR et al.
Biochimica Et Biophysica Acta. Proteins and Proteomics, 2018
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