Associated Papers
Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain.
Rizuan A et al.
Nature Communications, 2025
TDP-43 loss induces cryptic polyadenylation in ALS/FTD.
Bryce-Smith S et al.
Nature Neuroscience, 2025
Repulsive vs Attractive Crowding Distinctly Regulate TDP-43 Condensates through Region-specific Structural Dynamics.
Zhang G et al.
Jacs Au, 2025
Comprehensive mapping of mutations in TDP-43 and α-Synuclein that affect stability and binding.
Alamri SH et al.
Journal of Biomolecular Structure & Dynamics, 2025
Pathological Mutations D169G and P112H Electrostatically Aggravate the Amyloidogenicity of the Functional Domain of TDP-43.
Pillai M et al.
Acs Chemical Neuroscience, 2024
Decoding Missense Variants by Incorporating Phase Separation via Machine Learning.
Feng M et al.
Nature Communications, 2024
Structural details of helix-mediated TDP-43 C-terminal domain multimerization.
Rizuan A et al.
Biorxiv : the Preprint Server for Biology, 2024
The implications of physiological biomolecular condensates in amyotrophic lateral sclerosis.
Fakim H et al.
Seminars in Cell & Developmental Biology, 2024
TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD.
Bryce-Smith S et al.
Biorxiv : the Preprint Server for Biology, 2024
Dissecting the Effect of ALS Mutation G335D on the Early Aggregation of the TDP-43 Amyloidogenic Core Peptide: Helix-to-β-Sheet Transition and Conformational Shift.
Li F et al.
Journal of Chemical Information and Modeling, 2023
Role of Triggers on the Structural and Functional Facets of TAR DNA-binding Protein 43.
Camilus N et al.
Neuroscience, 2023
Atomistic Insights into A315E Mutation-Enhanced Pathogenicity of TDP-43 Core Fibrils.
Li F et al.
Acs Chemical Neuroscience, 2022
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire.
Hallegger M et al.
Cell, 2021
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells.
Yu H et al.
Science (new York, N.y.), 2021
TDP-43 α-helical structure tunes liquid-liquid phase separation and function.
Conicella AE et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020