Associated Papers
Is Predisposition to T2D Impacted by Polymorphisms in Genes Involved in Insulin Signaling and Cellular Bioenergetics?
Pati B et al.
Acta Physiologica (oxford, England), 2025
Clinical and Genetic Characteristics of Patients with Early-Onset Diabetes Involving at Least Two Consecutive Generations: Whole-Exome Sequencing in Probands from 25 Pedigrees.
Ran CQ et al.
Current Medical Science, 2025
Genetic architecture in Greenland is shaped by demography, structure and selection.
Stæger FF et al.
Nature, 2025
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise.
Kristensen JM et al.
Nature Metabolism, 2024
AS160 is a lipid-responsive regulator of cardiac Ca2+ homeostasis by controlling lysophosphatidylinositol metabolism and signaling.
Su S et al.
Nature Communications, 2024
MODY Only Monogenic? A Narrative Review of the Novel Rare and Low-Penetrant Variants.
Hasballa I et al.
International Journal of Molecular Sciences, 2024
Perspectives on genetic studies of type 2 diabetes from the genome-wide association studies era to precision medicine.
Imamura M et al.
Journal of Diabetes Investigation, 2024
Complex rearrangement in TBC1D4 in an individual with diabetes due to severe insulin resistance syndrome.
Cahn A et al.
European Journal of Human Genetics : Ejhg, 2024
The effect of traditional diet on glucose homoeostasis in carriers and non-carriers of a common TBC1D4 variant in Greenlandic Inuit: a randomised crossover study.
Lewis JI et al.
The British Journal of Nutrition, 2023
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland.
Overvad M et al.
International Journal of Circumpolar Health, 2023
Genetics of metabolic traits in Greenlanders.
Thuesen ACB et al.
Danish Medical Journal, 2023
Hereditary severe insulin resistance syndrome: Pathogenesis, pathophysiology, and clinical management.
Iqbal J et al.
Genes & Diseases, 2023
Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion.
Binsch C et al.
Cardiovascular Diabetology, 2023
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers.
Schnurr TM et al.
Diabetologia, 2021
Tissue-Specific Splicing and Dietary Interaction of a Mutant As160 Allele Determine Muscle Metabolic Fitness in Rodents.
Yang X et al.
Diabetes, 2021
The role of a traditional and western diet on glucose homeostasis in Greenlandic Inuit carriers and non-carriers of type 2 diabetes variant in the TBC1D4 gene: A protocol for a randomized clinical trial.
Møller G et al.
Contemporary Clinical Trials Communications, 2021
Unique roles of rare variants in the genetics of complex diseases in humans.
Momozawa Y et al.
Journal of Human Genetics, 2021
Insulin resistance and exaggerated insulin sensitivity triggered by single-gene mutations in the insulin signaling pathway.
Kushi R et al.
Diabetology International, 2021
Diabetes and Genetics: A Relationship Between Genetic Risk Alleles, Clinical Phenotypes and Therapeutic Approaches.
Sayed S et al.
Advances in Experimental Medicine and Biology, 2021
Clinical usefulness of multigene screening with phenotype-driven bioinformatics analysis for the diagnosis of patients with monogenic diabetes or severe insulin resistance.
Hosoe J et al.
Diabetes Research and Clinical Practice, 2020
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.
Ishigaki K et al.
Nature Genetics, 2020
The Impact of Pharmacogenomics in Personalized Medicine.
Singh DB
Advances in Biochemical Engineering/biotechnology, 2020
Genomics of disease risk in globally diverse populations.
Gurdasani D et al.
Nature Reviews. Genetics, 2019
Genetics of metabolic traits in Greenlanders: lessons from an isolated population.
Andersen MK et al.
Journal of Internal Medicine, 2018
Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population.
Grarup N et al.
Diabetologia, 2018
Design of Arab Diabetes Gene-Centric Array (ADGCA) in population with an epidemic of Type 2 Diabetes: A population specific SNP evaluation.
Al-Rubeaan K et al.
Gene, 2018
Regulation of RabGAPs involved in insulin action.
Mafakheri S et al.
Biochemical Society Transactions, 2018
Genomic insights into the causes of type 2 diabetes.
Langenberg C et al.
Lancet (london, England), 2018
Progress in defining the genetic contribution to type 2 diabetes susceptibility.
Morris AP
Current Opinion in Genetics & Development, 2018
Genetic Approaches to the Study of Gene Variants and Their Impact on the Pathophysiology of Type 2 Diabetes.
Szabo M et al.
Biochemical Genetics, 2018
Toward Precision Medicine: TBC1D4 Disruption Is Common Among the Inuit and Leads to Underdiagnosis of Type 2 Diabetes.
Manousaki D et al.
Diabetes Care, 2016
Genetics of Insulin Resistance and the Metabolic Syndrome.
Brown AE et al.
Current Cardiology Reports, 2016
Genetics of Type 2 Diabetes: the Power of Isolated Populations.
Andersen MK et al.
Current Diabetes Reports, 2016
Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland.
Zeggini E et al.
Diabetologia, 2016
Recent progress in genetic and epigenetic research on type 2 diabetes.
Kwak SH et al.
Experimental & Molecular Medicine, 2016
Genetics of type 2 diabetes-pitfalls and possibilities.
Prasad RB et al.
Genes, 2015
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes.
Moltke I et al.
Nature, 2014
Complex Genetics of Type 2 Diabetes and Effect Size: What have We Learned from Isolated Populations?
Nair AK et al.
The Review of Diabetic Studies : Rds, 0