Associated Papers
In vitro identification of decreased function genetic variants of ABCB1.
Suominen L et al.
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 2025
ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding?
Bruckmueller H et al.
Expert Opinion on Drug Metabolism & Toxicology, 2021
Ethnogeographic and inter-individual variability of human ABC transporters.
Xiao Q et al.
Human Genetics, 2020
The effect of ABCB1 polymorphisms on the outcome of breast cancer treatment.
Tulsyan S et al.
Pharmacogenomics and Personalized Medicine, 2016
Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever.
Dogruer D et al.
Genetics and Molecular Research : Gmr, 2013
Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability - considerations for drug development.
Lai Y et al.
Expert Opinion on Drug Metabolism & Toxicology, 2012
An update on ABCB1 pharmacogenetics: insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics.
Wolf SJ et al.
The Pharmacogenomics Journal, 2011
Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.
Man M et al.
Journal of Clinical Pharmacology, 2010
Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis.
Huebner C et al.
Inflammatory Bowel Diseases, 2009
Association of ABCB1 gene polymorphisms with plasma lipid and apolipoprotein concentrations in the STANISLAS cohort.
Jeannesson E et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 2009
A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.
Fung KL et al.
Biochimica Et Biophysica Acta, 2009
Substrate-dependent effects of human ABCB1 coding polymorphisms.
Gow JM et al.
The Journal of Pharmacology and Experimental Therapeutics, 2008
Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients.
Vaclavikova R et al.
Pharmacogenetics and Genomics, 2008
Pharmacogenetics as a tool for optimising drug therapy in solid-organ transplantation.
Ng FL et al.
Expert Opinion on Pharmacotherapy, 2007
Determination of ABCB1 polymorphisms and haplotypes frequencies in a French population.
Jeannesson E et al.
Fundamental & Clinical Pharmacology, 2007
ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.
Leschziner GD et al.
The Pharmacogenomics Journal, 2007
ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals.
Coller JK et al.
Clinical Pharmacology and Therapeutics, 2006
Cyp3A4, Cyp3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics in renal transplant recipients.
Roy JN et al.
Pharmacogenetics and Genomics, 2006
Implications of genetic polymorphisms in drug transporters for pharmacotherapy.
Kerb R
Cancer Letters, 2006
Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition.
Dey S
Expert Opinion on Drug Delivery, 2006
Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1).
Niemi M et al.
British Journal of Clinical Pharmacology, 2005
Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics.
Putnam WS et al.
Journal of Clinical Pharmacology, 2005
Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1).
Ishikawa T et al.
Biological & Pharmaceutical Bulletin, 2004
The MDR1 (ABCB1) gene polymorphism and its clinical implications.
Ieiri I et al.
Clinical Pharmacokinetics, 2004
MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.
Brant SR et al.
American Journal of Human Genetics, 2003
[MDR1 genotypes related to pharmacokinetics and MDR1 expression].
Nakamura T
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, 2003
MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males.
Gerloff T et al.
British Journal of Clinical Pharmacology, 2002
MDR1 genotype-related pharmacokinetics and pharmacodynamics.
Sakaeda T et al.
Biological & Pharmaceutical Bulletin, 2002
The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.
Siegmund W et al.
Clinical Pharmacology and Therapeutics, 2002
Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?
Lötsch J et al.
Anesthesiology, 2002
Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations.
Tang K et al.
Pharmacogenetics, 2002
C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation.
Goto M et al.
Pharmacogenetics, 2002
Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.
Kimchi-Sarfaty C et al.
Molecular Pharmacology, 2002
Naturally occurring mutations and functional polymorphisms in multidrug resistance 1 gene: correlation with microsatellite instability and lymphoid infiltration in colorectal cancers.
Potocnik U et al.
Journal of Medical Genetics, 2002
Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability.
Potocnik U et al.
Cellular & Molecular Biology Letters, 2002
Polymorphism of MDR1 gene in healthy japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys).
Honda T et al.
Drug Metabolism and Pharmacokinetics, 2002
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.
Cascorbi I et al.
Clinical Pharmacology and Therapeutics, 2001