Associated Papers
Glutamic Acid at Position 168 Is a Constitutive Activator of Tank Binding Kinase 1 Catalytic Function.
Bhore N et al.
Neuromolecular Medicine, 2025
TBK1 is a signaling hub in coordinating stress-adaptive mechanisms in head and neck cancer progression.
Kim HJ et al.
Autophagy, 2025
Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response.
Watanabe-Matsui M et al.
Iscience, 2025
Mechanistic insights into the interactions of TAX1BP1 with RB1CC1 and mammalian ATG8 family proteins.
Zhang M et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Optineurin provides a mitophagy contact site for TBK1 activation.
Yamano K et al.
The Embo Journal, 2024
NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
Paul S et al.
The Journal of Cell Biology, 2024
Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.
Wegner J et al.
Frontiers in Immunology, 2023
Clathrin-associated AP-1 controls termination of STING signalling.
Liu Y et al.
Nature, 2022
Specific association of TBK1 with the trans-Golgi network following STING stimulation.
Kemmoku H et al.
Cell Structure and Function, 2022
Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense.
Xie W et al.
Cell Death and Differentiation, 2022
Impact of single amino acid substitution on the structure and function of TANK-binding kinase-1.
Umair M et al.
Journal of Cellular Biochemistry, 2021
Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death.
Taft J et al.
Cell, 2021
ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy.
Harding O et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Deng Z et al.
Autophagy, 2020
Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity.
Ye J et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
The E3 Ubiquitin Ligase TBK1 Mediates the Degradation of Multiple Picornavirus VP3 Proteins by Phosphorylation and Ubiquitination.
Li D et al.
Journal of Virology, 2019
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis.
Pereira GC et al.
Mobile Dna, 2018
Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization.
Abe T et al.
Immunity, 2017
TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
van der Zee J et al.
Human Mutation, 2017
E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1.
Song G et al.
Nature Immunology, 2016
USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome.
Lin M et al.
Molecular Cell, 2016
Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.
Li F et al.
Nature Communications, 2016
Crystal structure of a human IκB kinase β asymmetric dimer.
Liu S et al.
The Journal of Biological Chemistry, 2013
Structural insights into the functions of TBK1 in innate antimicrobial immunity.
Shu C et al.
Structure (london, England : 1993), 2013
Crystal structure and mechanism of activation of TANK-binding kinase 1.
Larabi A et al.
Cell Reports, 2013
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.
Herman M et al.
The Journal of Experimental Medicine, 2012
NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.
Cui J et al.
Nature Immunology, 2012
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
Soulat D et al.
The Embo Journal, 2008