Associated Papers
TBK1 activity regulates the directionality of axonal transport of signalling endosomes.
Villarroel-Campos D et al.
Life Science Alliance, 2026
OPTN deficiency through CRISPR/Cas9 downregulates autophagy and mitophagy in a SOD1-G93A-expressing transgenic cell line.
Wen D et al.
Ibro Neuroscience Reports, 2025
Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks.
Smeyers J et al.
Cell Reports, 2025
Expanding the spectrum of annexin A11 proteinopathy in frontotemporal lobar degeneration and motor neuron disease.
Ghayal NB et al.
Acta Neuropathologica, 2025
Exploring TANK-Binding Kinase 1 in Amyotrophic Lateral Sclerosis: From Structural Mechanisms to Machine Learning-Guided Therapeutics.
Anjum F et al.
Life (basel, Switzerland), 2025
Inborn errors of canonical autophagy in neurodegenerative diseases.
Freisem D et al.
Human Molecular Genetics, 2025
ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice.
Lenoel I et al.
Nature Communications, 2025
Expanding the spectrum of annexin A11 proteinopathy in frontotemporal lobar degeneration and motor neuron disease.
Ghayal NB et al.
Biorxiv : the Preprint Server for Biology, 2025
Targeting mitophagy in neurodegenerative diseases.
Antico O et al.
Nature Reviews. Drug Discovery, 2025
TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models.
Raas Q et al.
Cell Death Discovery, 2025
The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Beckers J et al.
Autophagy Reports, 2025
A systematic review and functional in-silico analysis of genes and variants associated with amyotrophic lateral sclerosis.
Arreola-Aldape CA et al.
Frontiers in Neuroscience, 2025
The space-time continuum in neurological disorders of the autophagosome-lysosome fusion machinery.
Dafsari HS et al.
Autophagy Reports, 2025
The Underestimated Role of Iron in Frontotemporal Dementia: A Narrative Review.
Ferretti S et al.
International Journal of Molecular Sciences, 2024
Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD.
Adriaenssens E et al.
Nature Structural & Molecular Biology, 2024
Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition.
Talaia G et al.
The Embo Journal, 2024
Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations.
Nan H et al.
Alzheimer's Research & Therapy, 2024
A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
Brenner D et al.
The Journal of Experimental Medicine, 2024
Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition.
Talaia G et al.
Biorxiv : the Preprint Server for Biology, 2023
Genetic variability in sporadic amyotrophic lateral sclerosis.
Van Daele SH et al.
Brain : a Journal of Neurology, 2023
Emerging Trends in the Field of Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder.
De Marchi F et al.
Biomedicines, 2023
Unconventional initiation of PINK1/Parkin mitophagy by Optineurin.
Nguyen TN et al.
Molecular Cell, 2023
Gefitinib facilitates PINK1/Parkin-mediated mitophagy by enhancing mitochondrial recruitment of OPTN.
Li N et al.
Fundamental Research, 2022
Autophagy Dysfunction in ALS: from Transport to Protein Degradation.
Cozzi M et al.
Journal of Molecular Neuroscience : Mn, 2022
ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy.
Harding O et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021
ALS Genetics: Gains, Losses, and Implications for Future Therapies.
Kim G et al.
Neuron, 2020
ALS-Related Mutant SOD1 Aggregates Interfere with Mitophagy by Sequestering the Autophagy Receptor Optineurin.
Tak YJ et al.
International Journal of Molecular Sciences, 2020
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Deng Z et al.
Autophagy, 2020
Neuropathological characterization of a novel TANK binding kinase (TBK1) gene loss of function mutation associated with amyotrophic lateral sclerosis.
Weinreich M et al.
Neuropathology and Applied Neurobiology, 2020
Mendelian neurodegenerative disease genes involved in autophagy.
Stamatakou E et al.
Cell Discovery, 2020
Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity.
Ye J et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
Coexistence of variants in TBK1 and in other ALS-related genes elucidates an oligogenic model of pathogenesis in sporadic ALS.
Lattante S et al.
Neurobiology of Aging, 2019
The role of mitochondria in amyotrophic lateral sclerosis.
Smith EF et al.
Neuroscience Letters, 2019
Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunction.
McCombe PA et al.
Journal of Neurology, Neurosurgery, and Psychiatry, 2019
Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review.
Yu H et al.
Molecular Genetics & Genomic Medicine, 2019
ALS Genes in the Genomic Era and their Implications for FTD.
Nguyen HP et al.
Trends in Genetics : Tig, 2018
Optineurin Functions for Optimal Immunity.
Slowicka K et al.
Frontiers in Immunology, 2018
Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.
Ryan TA et al.
Frontiers in Immunology, 2018
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis.
Pereira GC et al.
Mobile Dna, 2018
TBK1 mutations in Italian patients with amyotrophic lateral sclerosis: genetic and functional characterisation.
Pozzi L et al.
Journal of Neurology, Neurosurgery, and Psychiatry, 2017
Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.
Goodwin JM et al.
Cell Reports, 2017
Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms.
Markovinovic A et al.
Progress in Neurobiology, 2017
Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway?
Khalil B et al.
Neural Regeneration Research, 2017
TBK1: a new player in ALS linking autophagy and neuroinflammation.
Oakes JA et al.
Molecular Brain, 2017